{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T08:10:23Z","timestamp":1742544623523,"version":"3.40.1"},"reference-count":0,"publisher":"Press of International Journal of Ophthalmology (IJO Press)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Ophthalmol"],"published-print":{"date-parts":[[2025,4,18]]},"abstract":"<jats:p>AIM: To assess tomographic changes and subclinical edema detection in Fuchs' endothelial corneal dystrophy (FECD) through Scheimpflug tomography in a group of phakic patients contemplating cataract surgery.\nMETHODS: A retrospective study was conducted on 30 phakic eyes from patients diagnosed with FECD but without clinical edema, and 59 phakic eyes from a control group without corneal alterations. Comprehensive ophthalmic examinations were conducted, including slit-lamp biomicroscopy, corneal specular microscopy (CSM), and Scheimpflug tomography.\nRESULTS: The study encompassed 30 phakic eyes with FECD (mean age 59.8\u00b113.1y) and 59 control eyes (mean age 61.3\u00b17.7y). The best-corrected visual acuity was higher in the control group compared to the FECD group [0 (0, 0.08) vs 0.05 (0, 0.15) logMAR; P=0.042]. CSM revealed significant differences between the FECD and control groups in several parameters: number of analyzed cells (26\u00b113 vs 135\u00b142, P&amp;#x003C;0.001), cell density (2049\u00b1376 vs 2479\u00b1225 cells\/mm2, P&amp;#x003C;0.001), mean cell area [463 (434, 544) vs 397 (383, 431) \u03bcm2; P&amp;#x003C;0.001], coefficient of variation (54.8%\u00b118.7% vs 41.0%\u00b17.2%, P&amp;#x003C;0.001), and hexagonal cells [0 (0, 47%) vs 47% (40%, 53%), P&amp;#x003C;0.001]. Although often used as a clinical parameter for detecting edema, central corneal thickness measured by CSM showed no significant difference between the FECD and control groups (530\u00b157 vs 546\u00b130 \u03bcm, P=0.179). Significant differences were noted in various Pentacam measurements between the groups. Specifically, parameters like loss of parallel isopachs (13 vs 0 eyes, P&amp;#x003C;0.001), displacement of the thinnest point (11 vs 0 eyes, P&amp;#x003C;0.001), posterior focal depression (25 vs 7 eyes, P&amp;#x003C;0.001), and increased light scatter [21.4 (17.6; 23.9) vs 18.0 (16.8, 21.8), P=0.01] were significantly more prevalent in FECD eyes, reflecting the presence of subclinical edema and loss of corneal transparency.\nCONCLUSION: Scheimpflug tomography allows for an objective assessment of FECD, offering the capability to detect subclinical edema at an early stage, monitor disease progression, and serve as a predictor of corneal decompensation following cataract surgery.<\/jats:p>","DOI":"10.18240\/ijo.2025.04.04","type":"journal-article","created":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T07:55:13Z","timestamp":1742543713000},"page":"590-597","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of tomographic parameters and detection of subclinical edema in Fuchs\u2019 endothelial corneal dystrophy pre-cataract surgery"],"prefix":"10.18240","volume":"18","author":[{"name":"Department of Ophthalmology, Unidade Local de Sa&#xFA;de Entre Douro e Vouga, Santa Maria da Feira 4520-211, Portugal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o","family":"Alves-Ambr\u00f3sio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catarina Pestana","family":"Aguiar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Ophthalmology, Unidade Local de Sa&#xFA;de Entre Douro e Vouga, Santa Maria da Feira 4520-211, Portugal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o","family":"Chibante-Pedro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Ophthalmology, Unidade Local de Sa&#xFA;de Entre Douro e Vouga, Santa Maria da Feira 4520-211, Portugal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In\u00eas","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Ophthalmology, Unidade Local de Sa&#xFA;de Entre Douro e Vouga, Santa Maria da Feira 4520-211, Portugal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7543","container-title":["International Journal of Ophthalmology"],"original-title":[],"link":[{"URL":"http:\/\/ies.ijo.cn\/en_publish\/2025\/4\/20250404.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T07:55:18Z","timestamp":1742543718000},"score":1,"resource":{"primary":{"URL":"http:\/\/ies.ijo.cn\/gjyken\/ch\/reader\/view_abstract.aspx?file_no=20250404&flag=1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,18]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4,18]]}},"URL":"https:\/\/doi.org\/10.18240\/ijo.2025.04.04","relation":{},"ISSN":["2222-3959","2227-4898"],"issn-type":[{"value":"2222-3959","type":"print"},{"value":"2227-4898","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,18]]}}}