{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:36:07Z","timestamp":1792629367817,"version":"4.5.0"},"reference-count":0,"publisher":"Press of International Journal of Ophthalmology (IJO Press)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Ophthalmol"],"published-print":{"date-parts":[[2025,4,18]]},"abstract":"<jats:p>AIM: To assess the variations in photoreceptor cell packing density (PCPD) across the retina among young healthy individuals with emmetropia, low and moderate myopia.\nMETHODS: High-resolution adaptive optics scanning laser ophthalmoscopy (AOSLO) systems were utilized for retinal imaging with a large sampling window of 700 \u03bcm\u00d7700 \u03bcm. The study cohort included 14 emmetropic [spherical equivalent (SE) ranged +0.5 to -0.5 D], 15 low myopic (SE ranged -0.5 to -3 D) and 21 moderate myopic (SE ranged -3 to -6 D) healthy young adults. Photoreceptors at 3\u00b0 temporal, 6\u00b0 superior and inferior 6\u00b0 were captured. Statistical analysis was then performed to obtain PCPD and cell spacing.\nRESULTS: The average age of participants was 22.54\u00b12.86 (ranged 20\u201330y) with no difference among 3 groups. At 3\u00b0 temporal, the emmetropic group exhibited the highest PCPD of 15 186.16\u00b12050.54 cells\/mm2, while the low and moderate myopic groups had PCPD of 14 009.15\u00b11073.01 and 13 466.92\u00b11121.71 cells\/mm2, respectively. At 3\u00b0 temporal, the emmetropic group also had the smallest cell spacing at 6.66\u00b10.26 mm, compared to 6.85\u00b10.26 and 6.91\u00b10.28 mm for the low and moderate myopic groups, respectively. Compared to the emmetropic group, at 3\u00b0 temporal, the myopic groups showed significantly reduced PCPD (low myopia: P=0.032; moderate myopia: P=0.001). At 6\u00b0 inferior, the moderate myopic group exhibited a significant decrease in PCPD (P=0.013), while at 6\u00b0 superior, there were no significant statistical differences in PCPD for the low and moderate myopic groups (P&amp;#x003E;0.05). In comparison to the emmetropic group, only the moderate myopic group showed significantly increased cell spacing at all three positions (temporal 3\u00b0: P=0.011, superior 6\u00b0: P=0.046, inferior 6\u00b0: P=0.013). Correlation analysis revealed a positive correlation between PCPD and axial length changes (P&amp;#x003C;0.05).\nCONCLUSION: Reduced PCPD and increased cell spacing strongly correlated with refractive error in mild to moderate myopic eyes, especially at 6\u00b0 inferior to the fovea and the decreased PCPD in the macular region of myopic patients may be associated with increased axial length-induced retinal stretching.<\/jats:p>","DOI":"10.18240\/ijo.2025.04.15","type":"journal-article","created":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T07:55:13Z","timestamp":1742543713000},"page":"683-690","source":"Crossref","is-referenced-by-count":2,"title":["Reduction of photoreceptor cell packing density in low or moderative myopia detected with adaptive optics scanning laser ophthalmoscopy"],"prefix":"10.18240","volume":"18","author":[{"name":"The Affiliated Eye Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China; The Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing 210029, Jiangsu Province, China","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin-Yi","family":"Lei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tang-Ren","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The Affiliated Eye Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China; The Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing 210029, Jiangsu Province, China","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Guo","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The Affiliated Eye Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China; The Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing 210029, Jiangsu Province, China","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The Affiliated Eye Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7543","container-title":["International Journal of Ophthalmology"],"original-title":[],"link":[{"URL":"http:\/\/ies.ijo.cn\/en_publish\/2025\/4\/20250415.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T07:55:34Z","timestamp":1742543734000},"score":1,"resource":{"primary":{"URL":"http:\/\/ies.ijo.cn\/gjyken\/ch\/reader\/view_abstract.aspx?file_no=20250415&flag=1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,18]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4,18]]}},"URL":"https:\/\/doi.org\/10.18240\/ijo.2025.04.15","relation":{},"ISSN":["2222-3959","2227-4898"],"issn-type":[{"value":"2222-3959","type":"print"},{"value":"2227-4898","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,18]]}}}