{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T02:13:55Z","timestamp":1776392035987,"version":"3.51.2"},"reference-count":0,"publisher":"Press of International Journal of Ophthalmology (IJO Press)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Ophthalmol"],"published-print":{"date-parts":[[2025,7,18]]},"abstract":"<jats:p>AIM: To compare the changes in preschool refractive status, ocular biological parameters, and higher-order aberrations in children with retinopathy of prematurity (ROP) after retinal laser photocoagulation or anti-vascular endothelial growth factor (anti-VEGF) treatment and explore their underlying factors.\nMETHODS: This observational study involved 118 eyes of 59 children, aged 3 to 6y, with ROP followed up between March 2023 and October 2024. They were divided into the laser, anti-VEGF, and anti-VEGF+laser groups. The laser group received a single session of laser photocoagulation. The anti-VEGF group received a single anti-VEGF treatment. The anti-VEGF+laser group received a single anti-VEGF treatment after birth followed by supplementary laser treatment within 2wk to 6mo. Ocular biological parameters were measured using IOL Master 700 and Pentacam HR. Right-eye higher-order aberrations were measured using the OPD-Scan III. Best-corrected visual acuities (BCVA), refractive statuses, ocular biological parameters, and higher-order aberrations were assessed and compared. Multiple linear regression analysis was conducted to evaluate the relationships among ocular biological parameters, higher-order aberrations, spherical equivalent (SE), and treatment methods. Pearson's correlation coefficients were used to assess the relationships between the SE and higher-order aberrations.\nRESULTS: The laser group had a higher incidence of myopia and a lower SE than the anti-VEGF group. The incidence of astigmatism and cylindrical power were significantly lower for the anti-VEGF than for the laser and anti-VEGF+laser groups (P&amp;#x003C;0.05). The anterior corneal surface astigmatism was higher for the laser and anti-VEGF+laser groups than for the anti-VEGF group. The anterior corneal surface K2 and lens thickness were higher for the laser and anti-VEGF+laser groups than for the anti-VEGF group. The whole-eye higher-order aberration root mean square (RMS) values for the right eye were significantly higher for the laser and anti-VEGF+laser groups than for the anti-VEGF group. The whole-eye trefoil RMS values for the right eye were also significantly higher for the laser and anti-VEGF+laser groups than for the anti-VEGF group (P&amp;#x003C;0.05). Laser treatment was significantly associated with SE, anterior corneal surface curvature and astigmatism, lens thickness, whole-eye high-order aberrations, and whole-eye trefoil (all P&amp;#x003C;0.05).\nCONCLUSION: Children with ROP who received laser treatment have higher myopia and astigmatism than those who received anti-VEGF treatment. Children treated with laser or supplementary laser treatment have higher anterior corneal astigmatism, anterior corneal curvature, thicker lenses, whole-eye higher-order aberrations, and whole-eye trefoil. The cause of myopia in children with ROP after laser treatment is increased anterior corneal surface curvature and lens thickness.<\/jats:p>","DOI":"10.18240\/ijo.2025.07.15","type":"journal-article","created":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T07:17:27Z","timestamp":1750403847000},"page":"1317-1325","source":"Crossref","is-referenced-by-count":1,"title":["Refractive status and ocular characteristics of preschool children with retinopathy of prematurity after different treatments"],"prefix":"10.18240","volume":"18","author":[{"name":"Department of Ophthalmology, Xijing Hospital, Air Force Medical University (Fourth Military Medical University), Eye Institute of Chinese PLA, Xi'an 710032, Shaanxi Province, China; Department of Ophthalmology, the 966th Hospital of the PLA Joint Logistic Support Force, Dandong 118000, Liaoning Province, China","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wu-Yang","family":"Jiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Ophthalmology, Xijing Hospital, Air Force Medical University (Fourth Military Medical University), Eye Institute of Chinese PLA, Xi'an 710032, Shaanxi Province, China","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Niu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Ophthalmology, Xijing Hospital, Air Force Medical University (Fourth Military Medical University), Eye Institute of Chinese PLA, Xi'an 710032, Shaanxi Province, China","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Sheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Ophthalmology, Xijing Hospital, Air Force Medical University (Fourth Military Medical University), Eye Institute of Chinese PLA, Xi'an 710032, Shaanxi Province, China","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi-Feng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Ophthalmology, Xijing Hospital, Air Force Medical University (Fourth Military Medical University), Eye Institute of Chinese PLA, Xi'an 710032, Shaanxi Province, China","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7543","container-title":["International Journal of Ophthalmology"],"original-title":[],"link":[{"URL":"http:\/\/ies.ijo.cn\/en_publish\/2025\/7\/20250715.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T07:17:31Z","timestamp":1750403851000},"score":1,"resource":{"primary":{"URL":"http:\/\/ies.ijo.cn\/gjyken\/ch\/reader\/view_abstract.aspx?file_no=20250715&flag=1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,18]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7,18]]}},"URL":"https:\/\/doi.org\/10.18240\/ijo.2025.07.15","relation":{},"ISSN":["2222-3959","2227-4898"],"issn-type":[{"value":"2222-3959","type":"print"},{"value":"2227-4898","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,18]]}}}