{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:46:57Z","timestamp":1792640817079,"version":"4.5.0"},"reference-count":0,"publisher":"Press of International Journal of Ophthalmology (IJO Press)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Ophthalmol"],"published-print":{"date-parts":[[2026,2,18]]},"abstract":"<jats:p>AIM: To evaluate the clinical features, diagnosis, treatment, and outcome of peripheral exudative hemorrhagic chorioretinopathy (PEHCR), a variant of polypoidal choroidal vasculopathy (PCV), in a case series of Chinese patients.\nMETHODS: This study was retrospectively conducted from September 2018 to March 2025. Clinical examinations included color fundus photography, B-scan ultrasonography, fluorescein angiography (FA), indocyanine green angiography (ICGA), swept-source optical coherence tomography (SS-OCT), and optical coherence tomography angiography (OCTA), and two active or inactive subgroups and misdiagnosed cases were analyzed.\nRESULTS: Totally 19 patients (21 eyes) with a mean age of 54.3\u00b19.4 (range, 36\u201368)y were included, with a majority of women (n=13, 68.4%). The mean follow-up period was 13\u00b11.4 (range: 1\u201357)mo. Decreased visual acuity was the most frequent initial manifestation (17 eyes, 84.2%), and lesions were mainly distributed in the inferotemporal or temporal quadrant (14 eyes, 66.7%), with choroidal polyps and branching neovascular networks revealed by OCTA and ICGA. Nine patients had been previously misdiagnosed with choroidal melanoma, and 6 of them had massive vitreous hemorrhage (VH). PEHCR manifested along a spectrum ranging from active or inactive subretinal hemorrhagic forms to chronic fibrotic or atrophic forms. One patient experienced natural regression. Ten eyes received a mean of 4.7\u00b11.1 (range: 3\u20137) intravitreal anti-vascular endothelial growth factor (VEGF) injections, two eyes underwent vitrectomy, and six eyes were treated with vitrectomy combined with anti-VEGF therapy. Best-corrected visual acuity (logMAR) in treated eyes (18 eyes) improved to 0.31\u00b10.25 from the baseline of 1.50?\u00b1?0.75 (P&lt;0.001).\nCONCLUSION: PEHCR is a variant of PCV. Chinese patients with PEHCR have a relatively younger age of onset. Anti-VEGF injections and\/or vitrectomy are treatment options for lesion regression or dense VH to gain better visual outcomes.<\/jats:p>","DOI":"10.18240\/ijo.2026.02.13","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T08:00:16Z","timestamp":1770883216000},"page":"312-319","source":"Crossref","is-referenced-by-count":1,"title":["Peripheral exudative hemorrhagic chorioretinopathy as a variant of polypoidal choroidal vasculopathy in a case series of Chinese patients"],"prefix":"10.18240","volume":"19","author":[{"name":"Beijing Tongren Eye Center, Beijing Ophthalmology &amp; Visual Sciences Key Lab, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jue-Xue","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Hong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Beijing Tongren Hospital, Beijing 100730, China","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Bin","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Beijing Tongren Eye Center, Beijing Ophthalmology &amp; Visual Sciences Key Lab, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7543","container-title":["International Journal of Ophthalmology"],"original-title":[],"link":[{"URL":"https:\/\/www.ijo.cn\/gjyken\/article\/pdf\/20260213.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T08:00:19Z","timestamp":1770883219000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ijo.cn\/gjyken\/article\/abstract\/20260213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,18]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2,18]]}},"URL":"https:\/\/doi.org\/10.18240\/ijo.2026.02.13","relation":{},"ISSN":["2222-3959","2227-4898"],"issn-type":[{"value":"2222-3959","type":"print"},{"value":"2227-4898","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,18]]}}}