{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T08:19:56Z","timestamp":1770884396890,"version":"3.50.1"},"reference-count":0,"publisher":"Press of International Journal of Ophthalmology (IJO Press)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Ophthalmol"],"published-print":{"date-parts":[[2026,2,18]]},"abstract":"<jats:p>AIM: To investigate the clinical characteristics and treatment outcomes, including visual function and overall survival (OS) of patients with ocular adnexal diffuse large B-cell lymphoma (OA-DLBCL).\nMETHODS: This retrospective cohort study enrolled 29 patients diagnosed with OA-DLBCL based on histopathological biopsy between 2006 and 2023. Patients were stratified into two subgroups: primary OA-DLBCL (no prior history of lymphoma) and secondary OA-DLBCL (history of DLBCL at non-ocular adnexal sites). OS was defined as the time interval from OA-DLBCL diagnosis to death from any cause. Survival analysis was performed using the Kaplan\u2013Meier method, and prognostic factors affecting OS were identified using multivariate Cox proportional hazards regression with a stepwise selection approach.\nRESULTS: The cohort included 24 patients with primary OA-DLBCL (13 males, 11 females; mean age: 61.36\u00b118.29y) and 5 patients with secondary OA-DLBCL (2 males, 3 females; mean age: 50.94\u00b118.17y). Among the primary OA-DLBCL subgroup, 12 patients (50%) presented with advanced disease (Ann Arbor stage IIIE\u2013IV), and 16 patients (66%) were classified as T4 disease according to the tumor-node-metastasis (TNM) staging system. The mean final visual acuity was 1.72\u00b11.10 in the primary group and 0.90\u00b11.18 in the secondary group. The 5-year OS rate for the entire cohort was 27.7%. Multivariate analysis identified five factors significantly associated with poor survival outcomes: epiphora [adjusted hazard ratio (aHR), 36.95], atherosclerotic cardiovascular disease (aHR, 10.08), human immunodeficiency virus (HIV) infection (aHR, 12.47), M1 stage (aHR, 6.99), and secondary OA-DLBCL (aHR, 6.03; all P&lt;0.05). The median OS was 1.68y for primary OA-DLBCL and 1.12y for secondary OA-DLBCL.\nCONCLUSION: A substantial proportion of patients with primary OA-DLBCL present with advanced-stage disease at diagnosis. Epiphora, atherosclerotic cardiovascular disease, HIV infection, M1 stage, and secondary OA-DLBCL are independent prognostic factors for poor survival outcomes. These findings emphasize the urgent need for optimized therapeutic strategies and early screening protocols to improve the management of OA-DLBCL, particularly in developing countries.<\/jats:p>","DOI":"10.18240\/ijo.2026.02.19","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T08:00:16Z","timestamp":1770883216000},"page":"354-361","source":"Crossref","is-referenced-by-count":0,"title":["Visual prognosis and survival outcomes in patients with ocular adnexal diffuse large B-cell lymphoma"],"prefix":"10.18240","volume":"19","author":[{"name":"Department of Ophthalmology, Faculty of Medicine, Prince of Songkla University, Kohong, Hat Yai, Songkhla 90110, Thailand","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sirawit","family":"Wainipitapong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panarat","family":"Noiperm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Hematology Unit, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Kohong, Hat Yai, Songkhla 90110, Thailand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mansing","family":"Ratanasukon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Ophthalmology, Faculty of Medicine, Prince of Songkla University, Kohong, Hat Yai, Songkhla 90110, Thailand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7543","container-title":["International Journal of Ophthalmology"],"original-title":[],"link":[{"URL":"https:\/\/www.ijo.cn\/gjyken\/article\/pdf\/20260219.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T08:00:20Z","timestamp":1770883220000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ijo.cn\/gjyken\/article\/abstract\/20260219"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,18]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2,18]]}},"URL":"https:\/\/doi.org\/10.18240\/ijo.2026.02.19","relation":{},"ISSN":["2222-3959","2227-4898"],"issn-type":[{"value":"2222-3959","type":"print"},{"value":"2227-4898","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,18]]}}}