{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T16:09:15Z","timestamp":1776355755689,"version":"3.51.2"},"reference-count":0,"publisher":"Press of International Journal of Ophthalmology (IJO Press)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Ophthalmol"],"published-print":{"date-parts":[[2026,3,18]]},"abstract":"<jats:p>AIM: To investigate the effects of zingerone (ZO) on the retina in diabetic rats.\nMETHODS: A total of 70 rats were randomly selected and divided into seven groups [diabetic group (Dm+; n=10), diabetic+metformin group (Dm+Met; n=10), diabetic+ZO25 group (Dm+ZO25; n=10), diabetic+ZO50 group (Dm+ZO50; n=10), diabetic+metformin group+ZO 50 Group (Dm+Met+ZO50; n=10)]. Diabetes was induced by streptozotocin (STZ), and metformin and two different doses of ZO were administered via gavage. Retinal tissues were evaluated by histopathological and immunohistochemical analyses.\nRESULTS: In diabetic rats, severe retinal inflammation, tissue necrosis, and increased tumor necrosis factor-\u03b1 (TNF-\u03b1) expression were observed. ZO administration reduced these effects in a dose-dependent manner. Protective effects of metformin alone were limited, and no synergistic benefit was observed in ZO+Met groups. Administration of 50 mg\/kg ZO to non-diabetic rats caused no retinal toxicity. Additionally, elevated 8-OHdG and c-Jun N-terminal kinase (JNK) expressions in diabetic retinopathy models were significantly reduced by ZO treatment.\nCONCLUSION: ZO can markedly reduce the pathological effects of the retina in a diabetic rat model.<\/jats:p>","DOI":"10.18240\/ijo.2026.03.04","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T07:23:54Z","timestamp":1770881034000},"page":"455-461","source":"Crossref","is-referenced-by-count":1,"title":["Protective effects of zingerone on the retina in diabetic rats"],"prefix":"10.18240","volume":"19","author":[{"name":"Ophthalmology, Erzurum Regional Training and Research Hospital, University of Health Sciences, Erzurum 25150, T&#xFC;rkiye","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bahadir","family":"Utlu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serkan","family":"Yildirim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Pathology, Atat&#xFC;rk University Faculty of Veterinary Medicine, Erzurum 25240, T&#xFC;rkiye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7543","container-title":["International Journal of Ophthalmology"],"original-title":[],"link":[{"URL":"https:\/\/www.ijo.cn\/gjyken\/article\/pdf\/20260304.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T07:55:11Z","timestamp":1770882911000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ijo.cn\/gjyken\/article\/abstract\/20260304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,18]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3,18]]}},"URL":"https:\/\/doi.org\/10.18240\/ijo.2026.03.04","relation":{},"ISSN":["2222-3959","2227-4898"],"issn-type":[{"value":"2222-3959","type":"print"},{"value":"2227-4898","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,18]]}}}