{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:05:13Z","timestamp":1793639113336,"version":"4.5.1"},"reference-count":0,"publisher":"Press of International Journal of Ophthalmology (IJO Press)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Ophthalmol"],"published-print":{"date-parts":[[2026,6,18]]},"abstract":"<jats:p>Breast cancer is the leading malignancy among women worldwide, with endocrine therapy (e.g., selective estrogen receptor modulators, aromatase inhibitors) serving as a cornerstone of treatment; although these therapies are effective against hormone-sensitive breast cancer, they alter patients\u2019 systemic hormone profiles, which may disrupt the balance of the ocular surface microbiota that maintains ocular homeostasis. This review systematically examines the mechanisms of mainstream breast cancer endocrine therapies, the dynamics of the ocular surface microbiota, the association between hormonal imbalance and ocular surface homeostasis, as well as the relationship between ocular surface flora alterations, and therapy-related ocular complications, integrating evidence from oncology, endocrinology, and ophthalmology to propose research frameworks and prevention strategies for therapy-related ocular complications.<\/jats:p>","DOI":"10.18240\/ijo.2026.06.21","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T08:10:26Z","timestamp":1779091826000},"page":"1194-1200","source":"Crossref","is-referenced-by-count":1,"title":["Breast cancer-related endocrine therapy on ocular surface microbiota: mechanism and clinical significance"],"prefix":"10.18240","volume":"19","author":[{"name":"Health Management Department, Qingdao Central Hospital, University of Health and Rehabilitation Sciences (Qingdao Central Hospital), Qingdao 266042, Shandong Province, China","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Yuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-Xia","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Health Management Department, Qingdao Central Hospital, University of Health and Rehabilitation Sciences (Qingdao Central Hospital), Qingdao 266042, Shandong Province, China","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Health Management Department, Qingdao Central Hospital, University of Health and Rehabilitation Sciences (Qingdao Central Hospital), Qingdao 266042, Shandong Province, China","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7543","container-title":["International Journal of Ophthalmology"],"original-title":[],"link":[{"URL":"https:\/\/www.ijo.cn\/gjyken\/article\/pdf\/20260621","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T08:10:34Z","timestamp":1779091834000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ijo.cn\/gjyken\/article\/abstract\/20260621"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,18]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6,18]]}},"URL":"https:\/\/doi.org\/10.18240\/ijo.2026.06.21","relation":{},"ISSN":["2222-3959","2227-4898"],"issn-type":[{"value":"2222-3959","type":"print"},{"value":"2227-4898","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,18]]}}}