{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:50:59Z","timestamp":1790013059894,"version":"4.0.1"},"reference-count":0,"publisher":"Press of International Journal of Ophthalmology (IJO Press)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Ophthalmol"],"published-print":{"date-parts":[[2026,7,18]]},"abstract":"<jats:p>AIM: To describe a case series of solitary punctate chorioretinitis (SPC), a subtype of punctate inner choroidopathy (PIC) characterized by solitary macular lesions.\nMETHODS: This retrospective, consecutive case series included patients diagnosed with SPC over a 5-year period, all of whom had a minimum follow-up of 6mo. Baseline and multimodal imaging data were analyzed to assess clinical presentations and prognosis.\nRESULTS: All patients (n=17) were Chinese and myopic, with a female predominance (12\/17, 70.6%). The mean age was 31y (range, 18\u201342y). The median refractive error of the affected eyes was -4.6 diopters (D; range, -14.5 to -0.75 D). Ophthalmoscopically, the lesions presented as solitary, yellow-white dots in the macula. On fundus fluorescein angiography (FFA), most lesions (15\/17, 88.2%) appeared hyperfluorescent, with slight leakage observed in 3 cases (17.6%). Indocyanine green angiography (ICGA) revealed hypofluorescence in nearly all cases (16\/17, 94.1%). Following a three-month course of oral glucocorticoids, most lesions (11\/17, 64.7%) showed reduction or resolution. During follow-up, five patients (29.4%) developed secondary macular neovascularization (MNV), indicating a more severe disease course. Recurrences were observed in six patients. At the final visit, focal choroidal excavation was present in four patients (23.5%).\nCONCLUSION: SPC is a rare subtype of PIC, characterized by a favorable prognosis, although late recurrences are possible. Accurate diagnosis necessitates differentiating it from MNV. Early intervention with oral glucocorticoids appears to be an effective therapeutic strategy.<\/jats:p>","DOI":"10.18240\/ijo.2026.07.12","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T06:15:16Z","timestamp":1781590516000},"page":"1316-1324","source":"Crossref","is-referenced-by-count":1,"title":["Clinical characteristics and prognosis of solitary punctate chorioretinitis in Chinese patients"],"prefix":"10.18240","volume":"19","author":[{"name":"Eye Center of Second Affiliated Hospital, Zhejiang Provincial Key Laboratory of Ophthalmology, Zhejiang Provincial Clinical Research Center for Eye Diseases, Zhejiang Provincial Engineering Institute on Eye Diseases, School of Medicine, Zhejiang University, Hangzhou 310009, Zhejiang Province, China;Co-first Authors: Ning-Xi Hong and Wei-Xin Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning-Xi","family":"Hong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Zhi","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Eye Center of Second Affiliated Hospital, Zhejiang Provincial Key Laboratory of Ophthalmology, Zhejiang Provincial Clinical Research Center for Eye Diseases, Zhejiang Provincial Engineering Institute on Eye Diseases, School of Medicine, Zhejiang University, Hangzhou 310009, Zhejiang Province, China;Co-first Authors: Ning-Xi Hong and Wei-Xin Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Eye Center of Second Affiliated Hospital, Zhejiang Provincial Key Laboratory of Ophthalmology, Zhejiang Provincial Clinical Research Center for Eye Diseases, Zhejiang Provincial Engineering Institute on Eye Diseases, School of Medicine, Zhejiang University, Hangzhou 310009, Zhejiang Province, China;Co-first Authors: Ning-Xi Hong and Wei-Xin Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan-Pan","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Eye Center of Second Affiliated Hospital, Zhejiang Provincial Key Laboratory of Ophthalmology, Zhejiang Provincial Clinical Research Center for Eye Diseases, Zhejiang Provincial Engineering Institute on Eye Diseases, School of Medicine, Zhejiang University, Hangzhou 310009, Zhejiang Province, China;Co-first Authors: Ning-Xi Hong and Wei-Xin Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7543","container-title":["International Journal of Ophthalmology"],"original-title":[],"link":[{"URL":"https:\/\/www.ijo.cn\/gjyken\/article\/pdf\/20260712","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T06:15:21Z","timestamp":1781590521000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ijo.cn\/gjyken\/article\/abstract\/20260712"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,18]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7,18]]}},"URL":"https:\/\/doi.org\/10.18240\/ijo.2026.07.12","relation":{},"ISSN":["2222-3959","2227-4898"],"issn-type":[{"value":"2222-3959","type":"print"},{"value":"2227-4898","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,18]]}}}