{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T06:32:21Z","timestamp":1786689141309,"version":"build-2736575974"},"reference-count":0,"publisher":"Press of International Journal of Ophthalmology (IJO Press)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Ophthalmol"],"published-print":{"date-parts":[[2026,9,18]]},"abstract":"<jats:p>AIM: To evaluate the efficacy and safety of micropulse transscleral laser therapy (MP-TLT) in lowering intraocular pressure (IOP) in eyes with primary glaucoma at different stages.\nMETHODS: In this retrospective longitudinal cohort study, data were collected from the charts of patients who undergo MP-TLT. Information regarding medication burden (including oral carbonic anhydrase inhibitor use), IOP, and visual acuity, were gathered prior to the procedure and at day 1, week 1 and at 1, 3, 6, 12, 18, and 24mo follow-up. Glaucoma severity staging was performed according to the Hodapp-Parrish-Anderson classification system based on visual field parameters assessed with standardized automated perimetry. Early glaucoma was defined as mean deviation (MD) better than -6 dB, moderate glaucoma as MD between -6 and -12 dB, and advanced glaucoma as MD worse than -12 dB.\nRESULTS: Totally 84 eyes of 53 patients (22 females), with a mean age of 67.14\u00b111.39y affected by progressive primary open angle glaucoma (POAG) and primary angle-closure glaucoma (PACG) were included. Before treatment, mean best corrected visual acuity was 0.26\u00b10.36 logMAR, mean IOP was 22.32\u00b16.64 mm Hg and patients took a mean of 2.96\u00b10.75 topical IOP lowering molecules; moreover, 18 patients also required acetazolamide tablets. At 1mo follow-up, a significant (P&amp;#x003C;0.001) reduction of mean IOP was detected both in POAG (-7.16\u00b12.92 mm Hg) and PACG (-6.89\u00b13.12 mm Hg) eyes, remaining stable during the further follow-up. A significant (P&amp;#x003C;0.01) reduction in the number of drugs taken was observed at 3-month follow-up both in POAG (-0.59\u00b10.32) and PACG (-1.06\u00b10.73) eyes. These effects persisted over time during the further follow-up. Furthermore, marked decreases in IOP and IOP-lowering drugs were seen in patients with early, moderate, and advanced glaucoma, and these results closely matched the findings from the entire study cohort.\nCONCLUSION: The results obtained suggest that MP-TLT may be an effective and safe option for managing patients with POAG and PACG at every stage of the disease.<\/jats:p>","DOI":"10.18240\/ijo.2026.09.08","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T06:15:08Z","timestamp":1786688108000},"page":"1731-1738","source":"Crossref","is-referenced-by-count":0,"title":["Safety and efficacy of micropulse transscleral laser therapy for glaucoma: a two-year follow-up"],"prefix":"10.18240","volume":"19","author":[{"name":"Multidisciplinary Department of Medical, Surgical and Dental Specialities, University of Campania Luigi Vanvitelli, Napoli 80100, Italy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Lanza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Ambrosio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Multidisciplinary Department of Medical, Surgical and Dental Specialities, University of Campania Luigi Vanvitelli, Napoli 80100, Italy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Abbate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Multidisciplinary Department of Medical, Surgical and Dental Specialities, University of Campania Luigi Vanvitelli, Napoli 80100, Italy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Boccia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Multidisciplinary Department of Medical, Surgical and Dental Specialities, University of Campania Luigi Vanvitelli, Napoli 80100, Italy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Serra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Multidisciplinary Department of Medical, Surgical and Dental Specialities, University of Campania Luigi Vanvitelli, Napoli 80100, Italy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Cangiano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Multidisciplinary Department of Medical, Surgical and Dental Specialities, University of Campania Luigi Vanvitelli, Napoli 80100, Italy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Simonelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Multidisciplinary Department of Medical, Surgical and Dental Specialities, University of Campania Luigi Vanvitelli, Napoli 80100, Italy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7543","container-title":["International Journal of Ophthalmology"],"original-title":[],"link":[{"URL":"https:\/\/www.ijo.cn\/gjyken\/article\/pdf\/20260908","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T06:15:11Z","timestamp":1786688111000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ijo.cn\/gjyken\/article\/abstract\/20260908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,18]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9,18]]}},"URL":"https:\/\/doi.org\/10.18240\/ijo.2026.09.08","relation":{},"ISSN":["2222-3959","2227-4898"],"issn-type":[{"value":"2222-3959","type":"print"},{"value":"2227-4898","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,18]]}}}