{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T06:32:23Z","timestamp":1786689143164,"version":"build-2736575974"},"reference-count":0,"publisher":"Press of International Journal of Ophthalmology (IJO Press)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Ophthalmol"],"published-print":{"date-parts":[[2026,9,18]]},"abstract":"<jats:p>AIM: To describe a modified technique using multiple-layer amniotic membrane (AM) to manage corneal perforations in graft-versus-host disease (GVHD).\nMETHODS: This case series included three eyes from 3 patients with GVHD and corneal perforation who underwent AM transplantation between 2019 and 2020. AM was collected from human placenta shortly after the cesarean section. During surgery, the AM was folded and sutured into the wound to create an \u201cAM pocket\u201d into which small AM debris was placed. The pocket was then closed using a 10-0 nylon suture and covered with an AM seal. After re-epithelization and AM scarring, sutures were removed.\nRESULTS: All 3 patients achieved successful wound closure with a single surgery, and corneal thickness remained &amp;#x003E;300 \u03bcm at the 6-month follow-up. Visual acuity improved in patients with peripheral perforation.\nCONCLUSION: The \u201cPocket\u201d AM transplantation technique is an effective option and recommend for treating acute corneal perforations in patients with GVHD. Our modified AM transplantation method provided definitive wound closure and successfully repaired wounds of various sizes without recurrent corneal melting or perforations.<\/jats:p>","DOI":"10.18240\/ijo.2026.09.22","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T06:15:08Z","timestamp":1786688108000},"page":"1878-1882","source":"Crossref","is-referenced-by-count":0,"title":["\u201cPocket\u201d technique: a multiple-layer amniotic membrane transplant approach for managing graft-versus-host disease-associated corneal perforations"],"prefix":"10.18240","volume":"19","author":[{"name":"Department of Ophthalmology, Peking University People's Hospital, Beijing 100044, China; Beijing Key Laboratory of Ocular Disease and Optometry Science, Peking University People's Hospital, Beijing 100044, China","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang-Ting","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Ophthalmology, Peking University People's Hospital, Beijing 100044, China; Beijing Key Laboratory of Ocular Disease and Optometry Science, Peking University People's Hospital, Beijing 100044, China; Xiamen Eye Center of Xiamen University, Xiamen 361000, Fujian Province, China","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7543","container-title":["International Journal of Ophthalmology"],"original-title":[],"link":[{"URL":"https:\/\/www.ijo.cn\/gjyken\/article\/pdf\/20260922","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T06:15:15Z","timestamp":1786688115000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ijo.cn\/gjyken\/article\/abstract\/20260922"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,18]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9,18]]}},"URL":"https:\/\/doi.org\/10.18240\/ijo.2026.09.22","relation":{},"ISSN":["2222-3959","2227-4898"],"issn-type":[{"value":"2222-3959","type":"print"},{"value":"2227-4898","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,18]]}}}