{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T08:20:41Z","timestamp":1789114841104,"version":"build-2803163510"},"reference-count":0,"publisher":"Press of International Journal of Ophthalmology (IJO Press)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Ophthalmol"],"published-print":{"date-parts":[[2026,10,18]]},"abstract":"<jats:p>AIM: To investigate the histological and anatomical characteristics of the lacrimal duct system (LDS) in rabbits and rats and compare with that in humans to establish a suitable animal for LDS studies.\nMETHODS: New Zealand white rabbits (1.8\u20132 kg) and SD rats (250\u2013300 g) were selected. Following tests were executed on their LDS, including anatomical measurements; computed tomographic dacryocystography; hematoxylin and eosin, Masson\u2019s trichrome, Periodic Acid-Schiff staining, and scanning electron microscope.\nRESULTS: Although there were anatomical similarities between the rats and humans in LDS, the size of LDS was too small and the epithelial types differed from that of humans in LDS. The rabbit only had a lower lacrimal punctum and a lacrimal canaliculus, while they had the same types of lacrimal epithelium as human\u2019s and the size was suitable for clinical probing and intubation.\nCONCLUSION: Histologically, the lacrimal canaliculi of both rabbits and rats resemble those of humans, making both species applicable for biological studies targeting the lacrimal canaliculi. Nevertheless, the epithelial types of the lacrimal sac and nasolacrimal duct in rats differ significantly from humans, whereas those in rabbits are consistent with humans. Therefore, rabbits are more appropriate for biological research involving the nasolacrimal duct and lacrimal sac.<\/jats:p>","DOI":"10.18240\/ijo.2026.10.04","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T07:25:34Z","timestamp":1789111534000},"page":"1906-1913","source":"Crossref","is-referenced-by-count":0,"title":["Suitability for lacrimal duct research: anatomical and histological evidence favors the rabbit model over the rat"],"prefix":"10.18240","volume":"19","author":[{"name":"Department of Ophthalmology, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China; National Key Clinical Specialty and Hubei Key Laboratory of Otolaryngologic and Ophthalmic Diseases, Wuhan 430030, Hubei Province, China","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun-Guo","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Ophthalmology, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China; National Key Clinical Specialty and Hubei Key Laboratory of Otolaryngologic and Ophthalmic Diseases, Wuhan 430030, Hubei Province, China","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Yang","family":"Ai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Ophthalmology, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China; National Key Clinical Specialty and Hubei Key Laboratory of Otolaryngologic and Ophthalmic Diseases, Wuhan 430030, Hubei Province, China","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-Yu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Ophthalmology, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China; National Key Clinical Specialty and Hubei Key Laboratory of Otolaryngologic and Ophthalmic Diseases, Wuhan 430030, Hubei Province, China","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Min","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Ophthalmology, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China; National Key Clinical Specialty and Hubei Key Laboratory of Otolaryngologic and Ophthalmic Diseases, Wuhan 430030, Hubei Province, China","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Ophthalmology, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China; National Key Clinical Specialty and Hubei Key Laboratory of Otolaryngologic and Ophthalmic Diseases, Wuhan 430030, Hubei Province, China","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7543","container-title":["International Journal of Ophthalmology"],"original-title":[],"link":[{"URL":"https:\/\/www.ijo.cn\/gjyken\/article\/pdf\/20261004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T07:25:35Z","timestamp":1789111535000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ijo.cn\/gjyken\/article\/abstract\/20261004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,18]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10,18]]}},"URL":"https:\/\/doi.org\/10.18240\/ijo.2026.10.04","relation":{},"ISSN":["2222-3959","2227-4898"],"issn-type":[{"value":"2222-3959","type":"print"},{"value":"2227-4898","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,18]]}}}