{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T08:20:55Z","timestamp":1789114855966,"version":"build-2803163510"},"reference-count":0,"publisher":"Press of International Journal of Ophthalmology (IJO Press)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Ophthalmol"],"published-print":{"date-parts":[[2026,10,18]]},"abstract":"<jats:p>AIM: To evaluate the structural and functional outcomes of accelerated epithelium-off corneal collagen cross-linking (CXL) in patients with keratoconus (KC) 1y after treatment.\nMETHODS: This retrospective study included patients who underwent an accelerated epi-off CXL for progressive KC at the Department of Ophthalmology, Sveti Duh University Hospital, Zagreb, Croatia, between January and December 2023. The protocol consisted of epithelial removal, riboflavin 0.1% instillation for 3min, and ultraviolet-A (UVA) irradiation at 9 mW\/cm2 for 10min. Pentacam HR was used to assess keratometric parameters (Kmax, Kmean), curvature-based indices [index of surface variance, index of vertical asymmetry, keratoconus index, central keratoconus index, index of height asymmetry (IHA), index of height decentration, minimum sagittal curvature (Rmin)], pachymetry-based indices [central corneal thickness (CCT), average pachymetric progression index, maximum Ambr\u00f3sio relational thickness], Belin\/Ambr\u00f3sio deviation, and the ABCD progression system preoperatively and at 12mo.\nRESULTS: A total of 45 eyes from 45 patients (mean age: 29.1\u00b16.2y) were included in the study. One year after CXL treatment, only Kmax front (55.20 to 55.00 D) showed a statistically significant decrease among the keratometric parameters. A statistically significant reduction was observed in all curvature-based indices, except for IHA, which did not reach statistical significance, whereas Rmin (6.11 to 6.14 mm) showed a statistically significant increase. Additionally, CCT, anterior radius of curvature (ARC), and best-corrected distance visual acuity (BCVA) also demonstrated statistically significant increase.\nCONCLUSION: Accelerated epi-off CXL results in significant structural and functional improvements in KC at the 1-year follow-up. Decreased Kmax and curvature indices, increased Rmin, CCT, and ARC, and improved BCVA indicate better corneal regularity, biomechanical stability, and functional vision, with ABCD analysis confirming disease stabilization.<\/jats:p>","DOI":"10.18240\/ijo.2026.10.10","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T07:25:34Z","timestamp":1789111534000},"page":"1964-1970","source":"Crossref","is-referenced-by-count":0,"title":["One-year structural and functional outcomes of accelerated epithelium-off corneal cross-linking in keratoconus"],"prefix":"10.18240","volume":"19","author":[{"name":"Department of Ophthalmology, Eye Department, Sveti Duh University Hospital, Zagreb 10000, Croatia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iva","family":"\u0106ubela","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daliborka","family":"Mileti\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Ophthalmology, Eye Department, Sveti Duh University Hospital, Zagreb 10000, Croatia; Faculty of Dental Medicine and Health Osijek, University Josip Juraj Strossmayer in Osijek, Osijek 31000, Croatia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biljana Kuzmanovi\u0107","family":"Elabjer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Ophthalmology, Eye Department, Sveti Duh University Hospital, Zagreb 10000, Croatia; Faculty of Medicine Osijek, University Josip Juraj Strossmayer in Osijek, Osijek 31000, Croatia; Faculty of Dental Medicine and Health Osijek, University Josip Juraj Strossmayer in Osijek, Osijek 31000, Croatia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senad","family":"Rami\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Ophthalmology, Eye Department, Sveti Duh University Hospital, Zagreb 10000, Croatia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Pavlovi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Ophthalmology, Eye Department, Sveti Duh University Hospital, Zagreb 10000, Croatia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean","family":"\u0160ari\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Ophthalmology, Eye Department, Sveti Duh University Hospital, Zagreb 10000, Croatia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mladen","family":"Bu\u0161i\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Ophthalmology, Eye Department, Sveti Duh University Hospital, Zagreb 10000, Croatia; Faculty of Medicine Osijek, University Josip Juraj Strossmayer in Osijek, Osijek 31000, Croatia; Faculty of Dental Medicine and Health Osijek, University Josip Juraj Strossmayer in Osijek, Osijek 31000, Croatia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7543","container-title":["International Journal of Ophthalmology"],"original-title":[],"link":[{"URL":"https:\/\/www.ijo.cn\/gjyken\/article\/pdf\/20261010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T07:25:37Z","timestamp":1789111537000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ijo.cn\/gjyken\/article\/abstract\/20261010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,18]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10,18]]}},"URL":"https:\/\/doi.org\/10.18240\/ijo.2026.10.10","relation":{},"ISSN":["2222-3959","2227-4898"],"issn-type":[{"value":"2222-3959","type":"print"},{"value":"2227-4898","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,18]]}}}