{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:51:26Z","timestamp":1790736686623,"version":"4.1.0"},"reference-count":122,"publisher":"Universidad Nacional de Lanus","license":[{"start":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T00:00:00Z","timestamp":1700092800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["SCOL"],"abstract":"<jats:p>El creciente campo de la reproducci\u00f3n humana asistida ha alcanzado hitos inimaginables. Su continuo desarrollo y las innovaciones que genera, en ocasiones, plantean dilemas tanto \u00e9ticos como jur\u00eddicos. El presente ensayo trata de exponer los cambios progresivos que se est\u00e1n viviendo en el \u00e1mbito del origen de la vida debido al desarrollo de nuevas opciones y estrategias en reproducci\u00f3n humana asistida. En primer lugar, se realiza una reflexi\u00f3n interdisciplinar desde la ciencia, la \u00e9tica y el derecho, sobre la naturaleza humana y los cambios a los que la sociedad se enfrenta, en particular, desde la perspectiva espa\u00f1ola. En segundo lugar, recoge una breve aproximaci\u00f3n en torno a las t\u00e9cnicas biom\u00e9dicas presentes o futuras en el campo de la reproducci\u00f3n humana. Concluye sobre la necesidad de reflexionar ante el vertiginoso avance de la ciencia en materia de reproducci\u00f3n humana asistida.<\/jats:p>","DOI":"10.18294\/sc.2023.4462","type":"journal-article","created":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T11:58:14Z","timestamp":1700222294000},"page":"e4462","source":"Crossref","is-referenced-by-count":1,"title":["Algunos dilemas \u00e9ticos presentes y futuros ante los avances en fecundaci\u00f3n in vitro"],"prefix":"10.18294","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2252-7199","authenticated-orcid":false,"given":"Marta","family":"Reguera Cabezas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7901","published-online":{"date-parts":[[2023,11,16]]},"reference":[{"key":"20741","unstructured":"Hall SS. Modificar nuestra herencia. Investigaci\u00f3n y Ciencia. 2016;(482):52-60."},{"key":"20742","doi-asserted-by":"crossref","unstructured":"Singer P. De compras por el supermercado gen\u00e9tico. Isegor\u00eda. 2002;(27):19-40.","DOI":"10.3989\/isegoria.2002.i27.552"},{"key":"20743","unstructured":"Savulescu J. Beneficencia procreativa: por qu\u00e9 debemos seleccionar los mejores ni\u00f1os. En: \u00bfDecisiones peligrosas? Una bio\u00e9tica desafiante. Madrid: Tecnos; 2012."},{"key":"20744","unstructured":"Harris J. The value of life: an introduction to medical ethics. London: Routledge; 2001."},{"key":"20745","unstructured":"Torres Quiroga MA. Maternidad y gestaci\u00f3n en venta: fabricar beb\u00e9s en la era neoliberal. Barcelona: Edicions de la Universitat de Barcelona; 2019."},{"key":"20746","unstructured":"European Parliament. Panel for the Future of Science and Technology (STOA). Human Enhancement [Internet]. 2009 [citado 25 mar 2023]. Disponible en: https:\/\/tinyurl.com\/mrxh8r3s."},{"key":"20747","doi-asserted-by":"crossref","unstructured":"Machin R, Plaza CA. The Latin Network of Researchers in Reproductive Biotechnologies: scientific cooperation and social debate in a global era. JBRA Assisted Reproduction. 2023;27(2):339.","DOI":"10.5935\/1518-0557.20230003"},{"key":"20748","unstructured":"Cortina A, Serra M\u00c0. Humanidad infinita: Desaf\u00edos \u00e9ticos de las tecnolog\u00edas emergentes. Madrid: Ediciones Internacionales Universitarias; 2016."},{"key":"20749","unstructured":"Gracia D. Bio\u00e9tica m\u00ednima. Espa\u00f1a: TRIACASTELA; 2019. p. 37."},{"key":"20750","doi-asserted-by":"crossref","unstructured":"Gleicher N, Kushnir VA, Barad DH. Worldwide decline of IVF birth rates and its probable causes. Human Reproduction Open. 2019;2019(3):1-7.","DOI":"10.1093\/hropen\/hoz017"},{"key":"20751","unstructured":"Nuffield Council on Bioethics. What\u2019s on the horizon for the Nuffield Council on Bioethics? [Internet]. 2023 [citado 9 nov 2023]. Disponible en: https:\/\/tinyurl.com\/2bupcv8z."},{"key":"20752","doi-asserted-by":"crossref","unstructured":"Singer P, Wells D. In vitro fertilisation: the major issues. Journal of Medical Ethics. 1983;9(4):192-195.","DOI":"10.1136\/jme.9.4.192"},{"key":"20753","doi-asserted-by":"crossref","unstructured":"Powell K. What\u2019s next for lab-grown human embryos? Nature. 2021;597:22-24.","DOI":"10.1038\/d41586-021-02343-7"},{"key":"20754","unstructured":"Esping-Andersen G, Arpino B, Baiz\u00e1n P, Bellani D, Castro-Mart\u00edn T, Creighton MJ, et al. El d\u00e9ficit de natalidad en Europa. Barcelona: Fundaci\u00f3n \u201cla Caixa\u201d; 2013."},{"key":"20755","unstructured":"P\u00e9rez Mil\u00e1n F, Weinig Mantorras R, Romeu Sarri\u00f3 AR, Coroleu Lletget B, (eds,). Libro Blanco Sociosanitario de la Infertilidad en Espa\u00f1a. Madrid: Imago Concept & Image Development SL; 2011"},{"key":"20756","unstructured":"Casabona R, Jim\u00e9nez N, Malanda R, (eds,). Reproducci\u00f3n humana. En: Idiakez AI. Manual de Bioderecho. Madrid: Dykinson; 2022. p. 223-248."},{"key":"20757","unstructured":"Rubio Castro AM. Sujeto, cuerpo y mercado: Una relaci\u00f3n compleja. En: Casado M, (ed,). De la solidad al mercado: el cuerpo humano y el comercio biotecnol\u00f3gico. Barcelona: Universidad de Barcelona; 2016. p. 65-96."},{"key":"20758","unstructured":"Rivas AM. Incentivos sociales\/laborales a la vitrificaci\u00f3n de \u00f3vulos: \u00bfMayor autonom\u00eda de las mujeres? Revista Jur\u00eddica Universidad Aut\u00f3noma de Madrid. 2017;(35):291-306."},{"key":"20759","doi-asserted-by":"crossref","unstructured":"von Schondorf-Gleicher A, Mochizuki L, Orvieto R, Patrizio P, Caplan AS, Gleicher N. Revisiting selected ethical aspects of current clinical in vitro fertilization (IVF) practice. 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Berkeley, California: Editorial de la Universidad de California; 2009.","DOI":"10.1525\/california\/9780520260436.001.0001"},{"key":"20786","unstructured":"Germ\u00e1n Zurriar\u00e1in R. El utilitarismo \u00e9tico en la investigaci\u00f3n biom\u00e9dica con embriones humanos. Persona Bio\u00e9tica. 2008;12(1):16-28."},{"key":"20787","doi-asserted-by":"crossref","unstructured":"Ledford H. CRISPR fixes disease gene in viable human embryos. Nature. 2017;548(7665):13-14.","DOI":"10.1038\/nature.2017.22382"},{"key":"20788","doi-asserted-by":"crossref","unstructured":"Cressey D, Abbott A, Ledford H. UK scientists apply for licence to edit genes in human embryos. Nature [Internet]. 2015 [citado 2 sep 2022]. Disponible en: https:\/\/tinyurl.com\/mwep2mhn.","DOI":"10.1038\/nature.2015.18394"},{"key":"20789","doi-asserted-by":"crossref","unstructured":"Savatier P, David L, Vos JD, Yates F, Tajbakhsh S, Martinat C. 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The end of pregnancy. The Guardian [Internet]. 2002 [citado 2 abr 2023]. Disponible en: https:\/\/tinyurl.com\/35mft7vt."},{"key":"20850","unstructured":"Solerte ML. Artificial uterus -research background to improve survival and outcome of extremely low birth weight newborns. Journal of gynecology research and obstetric. 2020;6(3):67-71."},{"key":"20851","unstructured":"Coutinho D. O \u201cfuturo\u201d da tecnologia reprodutiva: o \u00fatero artificial. 5\u00ba Congresso Internacional Direito na Lusofonia: Direito e novas tecnologias. Portugal; Universidade do Minho-Escola de Direito (ED); 2018."},{"key":"20852","doi-asserted-by":"crossref","unstructured":"Gelfand S, Shook JR, (eds). Ectogenesis. En: Singer P, Wells D. Ectogenesis: artificial womb technology and the future of human reproduction. Amsterdam, New York: Editions Rodopi BV; 2006.","DOI":"10.1163\/9789401203456"},{"key":"20853","unstructured":"Salam R. The End of Pregnancy. Slate [Internet]. 2014 [citado 2 abr 2023]. Disponible en: https:\/\/tinyurl.com\/564a43b5."},{"key":"20854","doi-asserted-by":"crossref","unstructured":"Di Stefano L, Mills C, Watkins A, Wilkinson D. Ectogestation ethics: The implications of artificially extending gestation for viability, newborn resuscitation and abortion. Bioethics. 2020;34(4):371-384.","DOI":"10.1111\/bioe.12682"},{"key":"20855","unstructured":"Kendal ES. Form, Function, Perception, and Reception: Visual Bioethics and the Artificial Womb. Yale Journal of Biology and Medicine. 2022;95(3):371-377."},{"key":"20856","doi-asserted-by":"crossref","unstructured":"Kendal ES. Unique benefits of ectogenesis outweigh potential harms. Emerging topics in life science. 2019;3(6):719-722.","DOI":"10.1042\/ETLS20190112"},{"key":"20857","unstructured":"Casabona R. El Convenio de Derechos Humanos y Biomedicina. Granada, Espa\u00f1a: Comares; 2002."},{"key":"20858","doi-asserted-by":"crossref","unstructured":"Kendal ES. The Perfect Womb: Promoting Equality of (Fetal) Opportunity. Journal of bioethical inquiry. 2017;14(2):185-194.","DOI":"10.1007\/s11673-017-9775-z"},{"key":"20859","doi-asserted-by":"crossref","unstructured":"Smajdor A. In Defense of Ectogenesis. Cambridge quarterly of healthcare ethics. 2012;21(1):90-103.","DOI":"10.1017\/S0963180111000521"},{"key":"20860","doi-asserted-by":"crossref","unstructured":"Romanis EC. Abortion & \u2018artificial wombs\u2019: would \u2018artificial womb\u2019 technology legally empower non-gestating genetic progenitors to participate in decisions about how to terminate pregnancy in England and Wales? J Law Biosci. 2021;8(1):lsab011.","DOI":"10.1093\/jlb\/lsab011"},{"key":"20861","doi-asserted-by":"crossref","unstructured":"Cohen IG. Artificial Wombs and Abortion Rights. The Hastings Center report. 2017;47(4):2-11.","DOI":"10.1002\/hast.730"},{"key":"20862","unstructured":"Izquierdo JM. Juan Luis Arsuaga: \u201cEs pronto para desaparecer como especie\u201d. 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