{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T11:40:59Z","timestamp":1792582859430,"version":"4.5.0"},"reference-count":0,"publisher":"Sultan Qaboos University","issue":"1","license":[{"start":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T00:00:00Z","timestamp":1746144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sultan Qaboos University Medical Journal"],"abstract":"<jats:p>The anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) usually manifests as systemic vasculitis. AAV with central nervous system involvement in the form of mesenrhombencephalitis and peripheral neuropathy is extremely rare. We report a 59-year-old male patient who presented to a tertiary care hospital in Muscat, Oman, in 2024. He had a subacute presentation of altered sensorium, multiple cranial nerve palsy and ataxia with 3 months history of bilateral foot drop. Brain imaging was suggestive of mesenrhombencephalitis with subarachnoid and intraparenchymal haemorrhage. Nerve conduction studies revealed sensorimotor axonal neuropathy. Vasculitis profile showed perinuclear-ANCA positivity and the nerve biopsy was suggestive of vasculitic neuropathy. He was treated with intravenous steroids and maintained on rituximab. His neurological deficits improved with residual bilateral foot drop.<\/jats:p>","DOI":"10.18295\/2075-0528.2820","type":"journal-article","created":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T05:39:57Z","timestamp":1746250797000},"page":"282-287","source":"Crossref","is-referenced-by-count":0,"title":["Anti-Neutrophil Cytoplasmic Antibody-Associated Central and Peripheral Nervous System Vasculitis"],"prefix":"10.18295","volume":"25","author":[{"given":"Abel T.","family":"Oommen","sequence":"first","affiliation":[{"name":"Department of Clinical Physiology, Sultan Qaboos University Hospital, University Medical City, Muscat, Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arunodaya R.","family":"Gujjar","sequence":"additional","affiliation":[{"name":"Department of Medicine, Sultan Qaboos University Hospital, University Medical City, Muscat, Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suad","family":"Al-Jahdhami","sequence":"additional","affiliation":[{"name":"Department of Pathology, Sultan Qaboos University Hospital, University Medical City, Muscat, Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah R.","family":"Al-Asmi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Sultan Qaboos University Hospital, University Medical City, Muscat, Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Sajjad","sequence":"additional","affiliation":[{"name":"Department of Medicine, Sultan Qaboos University Hospital, University Medical City, Muscat, Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7681","published-online":{"date-parts":[[2025,5,2]]},"container-title":["Sultan Qaboos University Medical Journal"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T10:58:15Z","timestamp":1792580295000},"score":1,"resource":{"primary":{"URL":"https:\/\/mjournal.squ.edu.om\/home\/vol25\/iss1\/35"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,2]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,5,2]]}},"URL":"https:\/\/doi.org\/10.18295\/2075-0528.2820","relation":{},"ISSN":["2075-0528"],"issn-type":[{"value":"2075-0528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,2]]}}}