{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T11:40:49Z","timestamp":1792582849661,"version":"4.5.0"},"reference-count":0,"publisher":"Sultan Qaboos University","issue":"1","license":[{"start":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T00:00:00Z","timestamp":1752192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sultan Qaboos University Medical Journal"],"abstract":"<jats:p>Objectives: This study aimed to assess the incidence of breast cancer in young women over a ten-year period and examine its association with clinical characteristics, risk factors, treatment modalities, and survival outcomes. Methods: A retrospective analysis of the Breast Cancer Registry at our institution was conducted. Of the 2,238 women diagnosed with breast cancer between 2012 and 2021, 535 (23.9%) were aged 40 years or younger at the time of diagnosis. Cases with missing data for independent variables were excluded from the respective analyses. Results: The mean age at diagnosis was 34.5 years (range: 15\u201340). The most common clinical stage at presentation was IIB (25.2%), followed by IIA (24.4%), while 7.6% of patients presented with metastatic disease. Invasive ductal carcinoma was the predominant histological type (88.8%), and 57.4% of tumours were high grade. Triple-negative breast cancer accounted for 27.0% of cases, and 18.4% were ERBB2-enriched. Bilateral disease was observed in 2.5% of cases, and 7.5% were diagnosed during pregnancy. A family history of breast cancer was reported in 23.6%. Genetic testing was performed in 10.9% of patients, with BRCA1 mutations being the most frequently identified (12.1%). Modified radical mastectomy was performed in 38.2% of patients, and 8.2% underwent reconstructive surgery. Neoadjuvant chemotherapy was administered in 49.9% of cases, and 68.2% received adjuvant radiotherapy. The five-year overall survival rate was 93.9%, with 12 patients (2.4%) experiencing distant and one (0.2%) experiencing local recurrence within five years. Conclusion: Young women with breast cancer in resource-limited settings demonstrate distinct sociodemographic and clinicopathological characteristics, underscoring the importance of early detection strategies and personalised treatment approaches.<\/jats:p>","DOI":"10.18295\/2075-0528.2886","type":"journal-article","created":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T12:45:11Z","timestamp":1752324311000},"page":"658-665","source":"Crossref","is-referenced-by-count":1,"title":["Unveiling the Clinicopathological Outcomes of Breast Cancer in Young Women: &lt;em&gt;A perspective from resource-limited settings&lt;\/em&gt;"],"prefix":"10.18295","volume":"25","author":[{"given":"Kulsoom","family":"Shaikh","sequence":"first","affiliation":[{"name":"Department of Breast Surgery, Aga Khan University Hospital, Karachi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiman","family":"Arif","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Aga Khan University Hospital, Karachi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehwish","family":"Mooghal","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Aga Khan University Hospital, Karachi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lubna","family":"Vohra","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Aga Khan University Hospital, Karachi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7681","published-online":{"date-parts":[[2025,7,11]]},"container-title":["Sultan Qaboos University Medical Journal"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T10:56:58Z","timestamp":1792580218000},"score":1,"resource":{"primary":{"URL":"https:\/\/mjournal.squ.edu.om\/home\/vol25\/iss1\/91"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,11]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,7,11]]}},"URL":"https:\/\/doi.org\/10.18295\/2075-0528.2886","relation":{},"ISSN":["2075-0528"],"issn-type":[{"value":"2075-0528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,11]]}}}