{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T11:40:30Z","timestamp":1792582830762,"version":"4.5.0"},"reference-count":0,"publisher":"Sultan Qaboos University","issue":"1","license":[{"start":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:00:00Z","timestamp":1766188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sultan Qaboos University Medical Journal"],"abstract":"<jats:p>This systematic review indicates that hydroxyurea may be a promising pharmacologic option for leukoreduction in paediatric critical pertussis. In reported cases, hydroxyurea was associated with leukocyte reduction and short-term survival. Its ability to potentially reduce the need for invasive leukoreductive procedures is especially relevant in resource-limited settings. While these observations are encouraging, the evidence base remains limited to a small number of uncontrolled case reports and case series, with inconsistent safety monitoring and no long-term follow-up. Given the very low certainty of the available evidence, these results should be considered preliminary and hypothesis-generating. Further well-designed, multicentre studies and randomised trials are urgently needed to confirm whether hydroxyurea can fulfil its potential as an effective and safe adjunctive treatment for this high-risk population.<\/jats:p>","DOI":"10.18295\/2075-0528.2937","type":"journal-article","created":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T08:13:46Z","timestamp":1766218426000},"page":"1135-1143","source":"Crossref","is-referenced-by-count":1,"title":["Therapeutic Role of Hydroxyurea in Paediatric Hydroxyurea Pertussis: &lt;em&gt;A systematic review&lt;\/em&gt;"],"prefix":"10.18295","volume":"25","author":[{"given":"Abdullah H.","family":"Alhamoud","sequence":"first","affiliation":[{"name":"Department of Pediatrics, King Fahad Central Hospital, Jazan Health Cluster, Ministry of Health, Jazan, Saudi Arabia; Pediatric Intensive Care Unit, Jazan General Hospital, Jazan Health Cluster, Ministry of Health, Jazan, Saudi Arabia AND Shared principal investigator"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Y.","family":"Suhaqi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, King Fahad Central Hospital, Jazan Health Cluster, Ministry of Health, Jazan, Saudi Arabia AND Department of General Hematology and Oncology, King Fahad Central Hospital, Jazan Health Cluster, Ministry of Health, Jazan, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qasem A.","family":"Arishi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology, Jazan Armed Forces Hospital, Ministry of Defense, Jazan, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahd Y.","family":"Somili","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, King Fahad Central Hospital, Jazan Health Cluster, Ministry of Health, Jazan, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan M.","family":"Gohal","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit, Prince Mohammed bin Nasser Hospital, Jazan Health Cluster, Ministry of Health, Jazan, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulaziz S.","family":"Almalki","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit, King Salman Armed Forces Hospital, Ministry of Defense, Tabuk, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed A.","family":"Eidoh","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit, Prince Sultan Military Medical City, Ministry of Defense, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadhel Y.","family":"Hazazi","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit, Jazan General Hospital, Jazan Health Cluster, Ministry of Health, Jazan, Saudi Arabia AND Shared principal investigator"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7681","published-online":{"date-parts":[[2025,12,20]]},"container-title":["Sultan Qaboos University Medical Journal"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T10:55:44Z","timestamp":1792580144000},"score":1,"resource":{"primary":{"URL":"https:\/\/mjournal.squ.edu.om\/home\/vol25\/iss1\/148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,20]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12,20]]}},"URL":"https:\/\/doi.org\/10.18295\/2075-0528.2937","relation":{},"ISSN":["2075-0528"],"issn-type":[{"value":"2075-0528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,20]]}}}