{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T21:41:21Z","timestamp":1793742081425,"version":"4.6.1"},"reference-count":36,"publisher":"European Publishing","issue":"July","license":[{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.tobaccoinduceddiseases.org"],"crossmark-restriction":false},"short-container-title":["Tob. Induc. Dis."],"DOI":"10.18332\/tid\/216384","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T18:50:42Z","timestamp":1784314242000},"page":"1-12","update-policy":"https:\/\/doi.org\/10.18332\/tid\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Examining the potential causal relationships among smoking, blood DNA methylation, and type 2 diabetes development: A Mendelian randomization study"],"prefix":"10.18332","volume":"24","author":[{"given":"Wenhua","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9041-720X","authenticated-orcid":false,"given":"Xizhen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7717","published-online":{"date-parts":[[2026,7,17]]},"reference":[{"key":"ref-1668582","doi-asserted-by":"publisher","DOI":"10.1001\/jama.298.22.2654"},{"key":"ref-1668583","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-152-1-201001050-00005"},{"key":"ref-1668584","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(18)30026-4"},{"key":"ref-1668585","unstructured":"U.S. Department of Health and Human Services. The Health Consequences\nof Smoking\u201450 Years of Progress: A Report of the Surgeon General. U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion Office on Smoking and Health; 2014. Accessed January 4, 2026. \nhttp:\/\/www.ncbi.nlm.nih.gov\/books\/NBK179276\/"},{"key":"ref-1668586","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a041302"},{"key":"ref-1668587","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-015-0148-3"},{"key":"ref-1668588","doi-asserted-by":"publisher","DOI":"10.2337\/db18-0537"},{"key":"ref-1668589","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-017-4497-7"},{"key":"ref-1668590","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-016-3872-0"},{"key":"ref-1668591","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2023.11.007"},{"key":"ref-1668592","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.18236"},{"key":"ref-1668593","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0307-5"},{"key":"ref-1668594","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.116.001506"},{"key":"ref-1668595","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-021-00923-x"},{"key":"ref-1668596","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0241-6"},{"key":"ref-1668597","doi-asserted-by":"publisher","DOI":"10.2337\/db16-1253"},{"key":"ref-1668598","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05473-8"},{"key":"ref-1668599","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-021-00931-x"},{"key":"ref-1668600","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyr036"},{"key":"ref-1668601","doi-asserted-by":"publisher","DOI":"10.1002\/sim.7221"},{"key":"ref-1668602","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyv080"},{"key":"ref-1668603","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.21758"},{"key":"ref-1668604","doi-asserted-by":"publisher","DOI":"10.1038\/335440a0"},{"key":"ref-1668605","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2011.12.022"},{"key":"ref-1668606","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2014.12.026"},{"key":"ref-1668607","doi-asserted-by":"publisher","DOI":"10.2337\/db09-0025"},{"key":"ref-1668608","doi-asserted-by":"publisher","DOI":"10.1038\/312721a0"},{"key":"ref-1668609","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-004-0556-x"},{"key":"ref-1668610","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-004-1659-1"},{"key":"ref-1668611","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0104486"},{"key":"ref-1668612","doi-asserted-by":"publisher","DOI":"10.1038\/ng.208"},{"key":"ref-1668613","doi-asserted-by":"publisher","DOI":"10.1038\/ng.207"},{"key":"ref-1668614","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2011.02.020"},{"key":"ref-1668615","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-012-2429-7"},{"key":"ref-1668616","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2023.1093882"},{"key":"ref-1668617","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-44841-y"}],"container-title":["Tobacco Induced Diseases"],"original-title":[],"link":[{"URL":"https:\/\/www.tobaccoinduceddiseases.org\/pdf-216384-142521","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tobaccoinduceddiseases.org\/pdf-216384-142521","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T18:50:43Z","timestamp":1784314243000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tobaccoinduceddiseases.org\/Examining-the-potential-causal-relationships-among-smoking-blood-DNA-methylation,216384,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,17]]},"references-count":36,"journal-issue":{"issue":"July","published-online":{"date-parts":[[2026]]}},"alternative-id":["216384"],"URL":"https:\/\/doi.org\/10.18332\/tid\/216384","relation":{},"ISSN":["1617-9625"],"issn-type":[{"value":"1617-9625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,17]]},"assertion":[{"value":"Research paper","name":"content_type","label":"Content type","group":{"name":"content_type"}},{"value":"Yes","name":"peer_reviewed","label":"Peer Reviewed","group":{"name":"peer_review","label":"Peer review"}},{"value":"Double blind","name":"review_process","label":"Review Process","group":{"name":"peer_review","label":"Peer review"}},{"value":"1 June 2025","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication history"}},{"value":"4 January 2026","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication history"}},{"value":"17 July 2026","name":"published","label":"Published","group":{"name":"publication_history","label":"Publication history"}},{"value":"\u00a9 2026 Li et al.","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and licensing"}},{"value":"This is an open access article distributed under the Creative Commons Attribution License (CC\u2011BY\u00a04.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited and its authors credited.","name":"license","label":"License","explanation":{"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},"group":{"name":"copyright_and_licensing","label":"Copyright and licensing"}}]}}