{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T12:27:05Z","timestamp":1753273625231,"version":"3.40.5"},"reference-count":0,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T00:00:00Z","timestamp":1699315200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Biochim Pol"],"abstract":"<jats:p>Objective: Circular RNAs (circRNAs) are enriched in the brain and involved in various central nervous system diseases. The potential role of circCCDC6 in cerebral ischemia-reperfusion defects was partly elucidated in the work. Methods: A middle cerebral artery occlusion\/reperfusion (MCAO\/R) rat model and an oxygen-glucose deprivation and re-oxygenation (OGD\/R)-treated SH-SY5Y cell model were constructed. CircCCDC6 expression in the two models was examined, and circCCDC6-involved mechanisms in neuronal pyroptosis and inflammation were analyzed through loss- and gain-of-function assays. Results: MCAO\/R rat brain tissues and OGD\/R-treated SH-SY5Y cells exhibited upregulated circCCDC6. Silencing circCCDC6 attenuated neuronal pyroptosis and inflammation in the brain tissue of MCAO\/R rats. Overexpressing circCCDC6 or inhibiting miR-128-3p stimulated OGD\/R-induced pyroptosis and inflammation in SH-SY5Y cells, while upregulating miR-128-3p attenuated OGD\/R injury. CircCCDC6 silencing-induced effects on SH-SY5Y cells were antagonized by TXNIP overexpression. Conclusion: Mechanistically, circCCDC6 mediates miR-128-3p and activates TXNIP\/NLRP3, thereby promoting OGD\/R-induced neuronal pyroptosis and inflammation. CircCCDC6 may provide a new strategy for the treatment of MCAO\/R.<\/jats:p>","DOI":"10.18388\/abp.2020_6552","type":"journal-article","created":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T16:35:40Z","timestamp":1699374940000},"source":"Crossref","is-referenced-by-count":2,"title":["Competitive binding of circCCDC6 to microRNA-128-3p  activates TXNIP\/NLRP3 pathway and promotes cerebral ischemia-reperfusion defects"],"prefix":"10.3389","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2166-7731","authenticated-orcid":false,"given":"ChongShu","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MingMing","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XiaoYi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XiaoYu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunpeng","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,11,7]]},"container-title":["Acta Biochimica Polonica"],"original-title":[],"link":[{"URL":"https:\/\/ojs.ptbioch.edu.pl\/index.php\/abp\/article\/download\/6552\/5905","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ojs.ptbioch.edu.pl\/index.php\/abp\/article\/download\/6552\/5905","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T13:53:54Z","timestamp":1716990834000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontierspartnerships.org\/articles\/10.18388\/abp.2020_6552\/pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,7]]},"references-count":0,"URL":"https:\/\/doi.org\/10.18388\/abp.2020_6552","relation":{},"ISSN":["1734-154X","0001-527X"],"issn-type":[{"type":"electronic","value":"1734-154X"},{"type":"print","value":"0001-527X"}],"subject":[],"published":{"date-parts":[[2023,11,7]]}}}