{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:13:45Z","timestamp":1790756025122,"version":"4.1.0"},"reference-count":0,"publisher":"Polskie Towarzystwo Biochemiczne (Polish Biochemical Society)","license":[{"start":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T00:00:00Z","timestamp":1599004800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Postepy Biochem"],"abstract":"<jats:p>Stwierdzono, \u017ce w obszarach o\u015brodkowego uk\u0142adu nerwowego (OUN) odpowiedzialnych za kontrol\u0119 \u0142aknienia dochodzi do ekspresji neurotroficznego czynnika pochodzenia m\u00f3zgowego (BDNF) oraz receptora TrkB. BDNF opr\u00f3cz zaanga\u017cowania w neurogenez\u0119, neuroprotekcj\u0119 oraz plastyczno\u015b\u0107 synaptyczn\u0105, wykazuje dzia\u0142anie anoreksygenne. Obni\u017cenie poziomu BDNF w m\u00f3zgu powoduje wzrost poboru pokarmu, a z kolei podawanie tego neuropeptydu do OUN prowadzi do obni\u017cenia masy cia\u0142a zwierz\u0105t. Pomimo, \u017ce mechanizm hamowania \u0142aknienia poprzez BDNF wci\u0105\u017c pozostaje niejasny, zauwa\u017cono, \u017ce neurotrofina ta mo\u017ce wsp\u00f3\u0142uczestniczy\u0107 z innymi czynnikami w regulacji przyjmowania pokarmu jak np. leptyn\u0105, insulin\u0105, cholecystokinin\u0105 czy kortykotropin\u0105. Ponadto mo\u017ce wp\u0142ywa\u0107 na gospodark\u0119 glukozy.Stwierdzono, \u017ce obwodowy poziom BDNF jest ni\u017cszy u os\u00f3b z anoreksj\u0105 w por\u00f3wnaniu z warto\u015bciami u os\u00f3b zdrowych, dodatkowo poziom BDNF ma tendencj\u0119 do wyr\u00f3wnania w trakcie powrotu do prawid\u0142owej masy cia\u0142a. Mutacja w genie BDNF mo\u017ce mie\u0107 r\u00f3wnie\u017c znaczenie w patogenezie oty\u0142o\u015bci, aczkolwiek dane co do st\u0119\u017cenia tej neurotrofiny we krwi u oty\u0142ych s\u0105 niejednoznaczne.<\/jats:p>","DOI":"10.18388\/pb.2020_340","type":"journal-article","created":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T19:07:38Z","timestamp":1599073658000},"source":"Crossref","is-referenced-by-count":5,"title":["Rola neurotroficznego czynnika pochodzenia m\u00f3zgowego w kontroli \u0142aknienia"],"prefix":"10.18388","author":[{"given":"Zofia","family":"Piotrowicz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Chalimoniuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi\u0142osz","family":"Czuba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f3zef","family":"Langfort","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7609","published-online":{"date-parts":[[2020,9,2]]},"container-title":["Post\u0119py Biochemii"],"original-title":[],"link":[{"URL":"https:\/\/postepybiochemii.ptbioch.edu.pl\/index.php\/PB\/article\/download\/340\/627","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/postepybiochemii.ptbioch.edu.pl\/index.php\/PB\/article\/download\/340\/627","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T19:07:38Z","timestamp":1599073658000},"score":1,"resource":{"primary":{"URL":"https:\/\/postepybiochemii.ptbioch.edu.pl\/index.php\/PB\/article\/view\/340"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,2]]},"references-count":0,"URL":"https:\/\/doi.org\/10.18388\/pb.2020_340","relation":{},"ISSN":["0032-5422"],"issn-type":[{"value":"0032-5422","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9,2]]}}}