{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T11:31:53Z","timestamp":1675683113825},"reference-count":0,"publisher":"Polskie Towarzystwo Biochemiczne (Polish Biochemical Society)","license":[{"start":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T00:00:00Z","timestamp":1609804800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Postepy Biochem"],"abstract":"<jats:p>Infekcje wirusowe przyczyniaj\u0105 si\u0119 do wielu nowotwor\u00f3w na ca\u0142ym \u015bwiecie i stanowi\u0105 istotny odsetek \u015bmiertelno\u015bci. Do onkogennych wirus\u00f3w zaliczany jest wirus Epsteina-Barr, kt\u00f3ry jest g\u0142\u00f3wn\u0105 przyczyn\u0105 mononukleozy zaka\u017anej i wykazuje tropizm wzgl\u0119dem limfocyt\u00f3w B. Dzi\u0119ki obecno\u015bci gen\u00f3w odpowiedzialnych za latencj\u0119 mo\u017ce przyczynia\u0107 si\u0119 do wielu stan\u00f3w patologicznych. Przyk\u0142adami tego s\u0105 nowotwory z\u0142o\u015bliwe o wysokiej \u015bmiertelno\u015bci zlokalizowane w \u017co\u0142\u0105dku, a tak\u017ce g\u0142owie oraz szyi. Ponadto wirus ten jest powa\u017cnym zagro\u017ceniem dla os\u00f3b z obni\u017con\u0105 odporno\u015bci\u0105, co stanowi w obecnych czasach istotny problem ze wzgl\u0119du na rosn\u0105c\u0105 liczb\u0119 chorych poddanych terapii immunosupresyjnej. Na szczeg\u00f3ln\u0105 uwag\u0119 w tym przypadku zas\u0142uguj\u0105 zaburzenia limfoproliferacyjnie po przeszczepie b\u0119d\u0105ce z\u0142o\u015bliwym nowotworem powi\u0105zanym z infekcj\u0105 EBV. W niniejszym przegl\u0105dzie skupiono si\u0119 na roli wirusa Epsteina-Barr w wybranych nowotworach.<\/jats:p>","DOI":"10.18388\/pb.2020_364","type":"journal-article","created":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T15:56:57Z","timestamp":1609862217000},"source":"Crossref","is-referenced-by-count":1,"title":["Wirus Epsteina-Barr w wybranych chorobach nowotworowych"],"prefix":"10.18388","author":[{"given":"Marcin","family":"Kole\u015bnik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Dworza\u0144ska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u0142gorzata","family":"Polz-Dacewicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7609","published-online":{"date-parts":[[2021,1,5]]},"container-title":["Post\u0119py Biochemii"],"original-title":[],"link":[{"URL":"https:\/\/postepybiochemii.ptbioch.edu.pl\/index.php\/PB\/article\/download\/364\/691","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/postepybiochemii.ptbioch.edu.pl\/index.php\/PB\/article\/download\/364\/691","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T15:56:58Z","timestamp":1609862218000},"score":1,"resource":{"primary":{"URL":"https:\/\/postepybiochemii.ptbioch.edu.pl\/index.php\/PB\/article\/view\/364"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,5]]},"references-count":0,"URL":"https:\/\/doi.org\/10.18388\/pb.2020_364","relation":{},"ISSN":["0032-5422"],"issn-type":[{"value":"0032-5422","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1,5]]}}}