{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T04:11:26Z","timestamp":1649218286974},"reference-count":0,"publisher":"Polskie Towarzystwo Biochemiczne (Polish Biochemical Society)","license":[{"start":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T00:00:00Z","timestamp":1614038400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Postepy Biochem"],"abstract":"<jats:p>Bia\u0142ka reguluj\u0105ce morfogenez\u0119 nask\u00f3rka zapewniaj\u0105 jego prawid\u0142owa budow\u0119 oraz funkcj\u0119. Mutacje w ich obr\u0119bie prowadz\u0105 do licznych zaburze\u0144 w pe\u0142nionej funkcji. Jednym z takich ostatnio opisanych bia\u0142ek jest kinaza bia\u0142kowa oddzia\u0142uj\u0105ca z receptorem kinaz serynowo-treoninowych 4 (RIPK4). Kinaza ta w nask\u00f3rku pe\u0142ni wa\u017cn\u0105 funkcj\u0119 regulatora homeostazy pomi\u0119dzy proliferacja a r\u00f3\u017cnicowaniem si\u0119 keratynocyt\u00f3w. Mutacje w obr\u0119bie genu koduj\u0105cego bia\u0142ko RIPK4 skutkuj\u0105 u ludzi letalnym zespo\u0142em Bartsocas-Papas lub zespo\u0142em mnogich p\u0142etwisto\u015bci typu Aslana, a jego delecja u myszy (Ripk4-\/-) prowadzi do przedwczesnej \u015bmierci noworodk\u00f3w spowodowanej licznymi zrostami sk\u00f3rnymi. RIPK4 odgrywa rol\u0119 w stanie zapalnym sk\u00f3ry. Sugeruje si\u0119, \u017ce bia\u0142ko to w sk\u00f3rze pe\u0142ni rol\u0119 supresora nowotwor\u00f3w, poniewa\u017c jego poziom zmniejsza si\u0119 w rakach kolczystokom\u00f3rkowych wzgl\u0119dem sk\u00f3ry zdrowej, a jego indukowana delecja w modelu mysim sprzyja powstawaniu i rozrostowi brodawczak\u00f3w i rak\u00f3w kolczystokom\u00f3rkowych wywo\u0142ywanych na drodze chemicznej. W pracy om\u00f3wiono rodzin\u0119 bia\u0142ek RIP, udzia\u0142 bia\u0142ka RIPK4 w r\u00f3\u017cnicowaniu si\u0119 nask\u00f3rka i szlakach sygnalizacyjnych, a tak\u017ce konsekwencje zaburze\u0144 wywo\u0142anych jego nieprawid\u0142ow\u0105 ekspresj\u0105.<\/jats:p>","DOI":"10.18388\/pb.2021_370","type":"journal-article","created":{"date-parts":[[2021,2,28]],"date-time":"2021-02-28T21:14:50Z","timestamp":1614546890000},"source":"Crossref","is-referenced-by-count":0,"title":["Rola bia\u0142ka RIPK4 w fizjologii nask\u00f3rka."],"prefix":"10.18388","author":[{"given":"Agnieszka","family":"Wolnicka-G\u0142ubisz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewelina","family":"Madej","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Lisek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7609","published-online":{"date-parts":[[2021,2,23]]},"container-title":["Post\u0119py Biochemii"],"original-title":[],"link":[{"URL":"https:\/\/postepybiochemii.ptbioch.edu.pl\/index.php\/PB\/article\/download\/370\/725","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/postepybiochemii.ptbioch.edu.pl\/index.php\/PB\/article\/download\/370\/725","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,28]],"date-time":"2021-02-28T21:14:51Z","timestamp":1614546891000},"score":1,"resource":{"primary":{"URL":"https:\/\/postepybiochemii.ptbioch.edu.pl\/index.php\/PB\/article\/view\/370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,23]]},"references-count":0,"URL":"https:\/\/doi.org\/10.18388\/pb.2021_370","relation":{},"ISSN":["0032-5422"],"issn-type":[{"value":"0032-5422","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2,23]]}}}