{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T15:17:08Z","timestamp":1692026228521},"reference-count":0,"publisher":"Polskie Towarzystwo Biochemiczne (Polish Biochemical Society)","license":[{"start":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T00:00:00Z","timestamp":1619395200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Postepy Biochem"],"abstract":"<jats:p>Leczenie chor\u00f3b neurodegeneracyjnych, schorze\u0144 charakteryzuj\u0105cych si\u0119 post\u0119puj\u0105c\u0105 utrat\u0105 kom\u00f3rek nerwowych, stanowi ogromne wyzwanie wsp\u00f3\u0142czesnej medycyny. Poszukiwanie lek\u00f3w na te choroby trwa w wielu laboratoriach na \u015bwiecie. Do dnia dzisiejszego zaproponowano kilka strategii terapeutycznych, kt\u00f3re nie wykazuj\u0105 jednak wystarczaj\u0105cej skuteczno\u015bci albo s\u0105 jeszcze na wczesnym etapie bada\u0144 przedklinicznych. Jednym z najnowszych podej\u015b\u0107 do terapii jest przyspieszona degradacja agregat\u00f3w bia\u0142kowych, kt\u00f3re stanowi\u0105 przyczyn\u0119 a\u017c 70% tych schorze\u0144. Procesem, kt\u00f3ry m\u00f3g\u0142by zosta\u0107 wykorzystany w tym celu jest autofagia czyli lizosomalna degradacja makrocz\u0105steczek kt\u00f3ra odpowiednio zaindukowana mog\u0142aby doprowadzi\u0107 do takiego efektu. Poszukiwania zwi\u0105zku, kt\u00f3ry nie tylko aktywowa\u0142by autofagi\u0119 ale by\u0142 tak\u017ce bezpieczny w d\u0142ugoterminowym stosowaniu oraz przekracza\u0142 barier\u0119 krew-m\u00f3zg doprowadzi\u0142y do bada\u0144 nad jednym z flawonoid\u00f3w, genistein\u0105, kt\u00f3rego szczeg\u00f3lnie du\u017ce st\u0119\u017cenia mo\u017cna znale\u017a\u0107 w soi. Badania przeprowadzone nad tym flawonoidem wskaza\u0142y jego niezwyk\u0142\u0105 skuteczno\u015b\u0107 w usuwaniu agregat\u00f3w bia\u0142kowych tworzonych przez \u00ce\u02db-amyloid i hiperfosforylowan\u0105 form\u0119 bia\u0142ka tau, a tak\u017ce zmutowan\u0105 huntingtyn\u0119. Co wi\u0119cej, u zwierz\u0105t b\u0119d\u0105cych modelami tych chor\u00f3b wskazano na ca\u0142kowite zniesienie kognitywnych i motorycznych objaw\u00f3w. Z uwagi na wysokie bezpiecze\u0144stwo stosowania genisteiny oraz fakt, \u017ce przekracza ona barier\u0119 krew-m\u00f3zg, izoflawon ten jest kandydatem na skuteczny lek w leczeniu nie tylko choroby Alzheimera i Huntingtona ale tak\u017ce innych chor\u00f3b spowodowanych agregacj\u0105 bia\u0142ek. W manuskrypcie przedstawiono najnowsze dane dotycz\u0105ce bada\u0144 nad zastosowaniem genisteiny w modelach chor\u00f3b neurodegeneracyjnych ze szczeg\u00f3lnym naciskiem na jej dzia\u0142anie zale\u017cne od procesu autofagii.<\/jats:p>","DOI":"10.18388\/pb.2021_380","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T20:08:20Z","timestamp":1619467700000},"source":"Crossref","is-referenced-by-count":2,"title":["Potencja\u0142 autofagii indukowanej przez genistein\u0119 2 w leczeniu chor\u00f3b neurodegeneracyjnych"],"prefix":"10.18388","author":[{"given":"Karolina","family":"Pierzynowska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuzanna","family":"Cyske","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lidia","family":"Gaffke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Estera","family":"Rintz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jagoda","family":"Mantej","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Podlacha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karolina","family":"Wi\u015bniewska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"\u0139\u0165abi\u0144ska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maja","family":"Sochocka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patryk","family":"Lorenc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrycja","family":"Biela\u0144ska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izabela","family":"Giecewicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grzegorz","family":"W\u0119grzyn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7609","published-online":{"date-parts":[[2021,4,26]]},"container-title":["Post\u0119py Biochemii"],"original-title":[],"link":[{"URL":"https:\/\/postepybiochemii.ptbioch.edu.pl\/index.php\/PB\/article\/download\/380\/771","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/postepybiochemii.ptbioch.edu.pl\/index.php\/PB\/article\/download\/380\/771","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T20:08:20Z","timestamp":1619467700000},"score":1,"resource":{"primary":{"URL":"https:\/\/postepybiochemii.ptbioch.edu.pl\/index.php\/PB\/article\/view\/380"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,26]]},"references-count":0,"URL":"https:\/\/doi.org\/10.18388\/pb.2021_380","relation":{},"ISSN":["0032-5422"],"issn-type":[{"value":"0032-5422","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4,26]]}}}