{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T19:11:19Z","timestamp":1653851479689},"reference-count":0,"publisher":"Polskie Towarzystwo Biochemiczne (Polish Biochemical Society)","license":[{"start":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T00:00:00Z","timestamp":1653350400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Postepy Biochem"],"abstract":"<jats:p>Receptory sprz\u0119\u017cone z bia\u0142kiem G stanowi\u0105 najwi\u0119ksz\u0105 rodzin\u0119 receptor\u00f3w b\u0142onowych i bior\u0105 udzia\u0142 w licznych procesach utrzymuj\u0105cych homeostaz\u0119 organizmu. Cz\u0119\u015b\u0107 tych receptor\u00f3w nadal jest zaliczana do receptor\u00f3w sierocych, poniewa\u017c\u00a0 ich funkcja i endogenne ligandy nie s\u0105 dok\u0142adnie poznane.\u00a0 Przez d\u0142ugi czas receptor GPR18 by\u0142 zaliczany do tej grupy, a niedawno zosta\u0142 sklasyfikowany jako receptor endokannabinoidowy, poniewa\u017c wykazano jego powinowactwo do ligand\u00f3w kannabinoidowych. Ekspresja receptora GPR18 zosta\u0142a wykazana m.in. w m\u00f3zgowiu, tarczycy, leukocytach krwi obwodowej, p\u0142ucach oraz j\u0105drach. Udowodniono jego rol\u0119 w regulacji ci\u015bnienia \u015br\u00f3dga\u0142kowego, neuroimmunomodulacji, regulacji ci\u015bnienia t\u0119tniczego oraz w zaburzeniach metabolicznych. W niniejszym artykule podsumowujemy aktualny stan wiedzy dotycz\u0105cej receptora GPR18 - jego ekspresji w organizmie, ligand\u00f3w oraz roli w procesach fizjologicznych, jak i patofizjologii.<\/jats:p>","DOI":"10.18388\/pb.2021_399","type":"journal-article","created":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T18:55:53Z","timestamp":1653850553000},"source":"Crossref","is-referenced-by-count":0,"title":["Receptor GPR18 \u2013 budowa, funkcja i rola w fizjologii i patofizjologii"],"prefix":"10.18388","author":[{"given":"Michalina","family":"Jurkiewicz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greta","family":"Ste\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Szczepaniak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakub","family":"Fichna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Zieli\u0144ska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7609","published-online":{"date-parts":[[2022,5,24]]},"container-title":["Post\u0119py Biochemii"],"original-title":[],"link":[{"URL":"https:\/\/postepybiochemii.ptbioch.edu.pl\/index.php\/PB\/article\/download\/399\/1013","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/postepybiochemii.ptbioch.edu.pl\/index.php\/PB\/article\/download\/399\/1014","content-type":"image\/png","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/postepybiochemii.ptbioch.edu.pl\/index.php\/PB\/article\/download\/399\/1013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T18:55:53Z","timestamp":1653850553000},"score":1,"resource":{"primary":{"URL":"https:\/\/postepybiochemii.ptbioch.edu.pl\/index.php\/PB\/article\/view\/399"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,24]]},"references-count":0,"URL":"https:\/\/doi.org\/10.18388\/pb.2021_399","relation":{},"ISSN":["0032-5422"],"issn-type":[{"value":"0032-5422","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5,24]]}}}