{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T19:27:35Z","timestamp":1648668455938},"reference-count":0,"publisher":"Polskie Towarzystwo Biochemiczne (Polish Biochemical Society)","license":[{"start":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T00:00:00Z","timestamp":1636416000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Postepy Biochem"],"abstract":"<jats:p>Mi\u0119\u015bnie szkieletowe s\u0105 wysoce wyspecjalizowan\u0105 tkank\u0105 zwierz\u0119c\u0105, kt\u00f3rej podstawow\u0105 funkcj\u0105 jest skurcz, przek\u0142adaj\u0105cy si\u0119 na ruch zwierz\u0105t. Jednym z typ\u00f3w mi\u0119\u015bni szkieletowych s\u0105 mi\u0119\u015bnie tu\u0142owia (miotomalne) nale\u017c\u0105ce u kr\u0119gowc\u00f3w do najstarszej filogenetycznie grupy mi\u0119\u015bni. Por\u00f3wnawcze badania miogenezy miotomalnej wykaza\u0142y, \u017ce mi\u0119\u015bnie te maj\u0105 podobny plan budowy, jednak mimo kontroli przez te same czynniki genetycznych, mog\u0105 r\u00f3\u017cnicowa\u0107 si\u0119 odmiennie u poszczeg\u00f3lnych gatunk\u00f3w kr\u0119gowc\u00f3w (zar\u00f3wno u gatunk\u00f3w modelowych jak i niemodelowych). Poznanie mechanizm\u00f3w rozwoju mi\u0119\u015bni szkieletowych jest warunkiem sine qua non w zrozumieniu stan\u00f3w chorobowych tkanki mi\u0119\u015bniowej obserwowanych u ludzi. W pracy podsumowano aktualn\u0105 wiedz\u0119 dotycz\u0105c\u0105 r\u00f3\u017cnicowania mi\u0119\u015bni szkieletowych zwierz\u0105t, stan\u00f3w patologicznych mi\u0119\u015bni spowodowanych mutacjami w genach bia\u0142ek strukturalnych oraz metabolicznych mi\u0119\u015bni.<\/jats:p>","DOI":"10.18388\/pb.2021_411","type":"journal-article","created":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T19:28:52Z","timestamp":1638473332000},"source":"Crossref","is-referenced-by-count":0,"title":["Czego jeszcze nie wiemy o mi\u0119\u015bniach szkieletowych?"],"prefix":"10.18388","author":[{"given":"Marta","family":"Migocka-Patrza\u0142ek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magda","family":"Dubi\u0144ska-Magiera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damian","family":"Lewandowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Elias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u0142gorzata","family":"Daczewska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7609","published-online":{"date-parts":[[2021,11,9]]},"container-title":["Post\u0119py Biochemii"],"original-title":[],"link":[{"URL":"https:\/\/postepybiochemii.ptbioch.edu.pl\/index.php\/PB\/article\/download\/411\/890","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/postepybiochemii.ptbioch.edu.pl\/index.php\/PB\/article\/download\/411\/891","content-type":"image\/jpeg","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/postepybiochemii.ptbioch.edu.pl\/index.php\/PB\/article\/download\/411\/890","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T19:28:52Z","timestamp":1638473332000},"score":1,"resource":{"primary":{"URL":"https:\/\/postepybiochemii.ptbioch.edu.pl\/index.php\/PB\/article\/view\/411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,9]]},"references-count":0,"URL":"https:\/\/doi.org\/10.18388\/pb.2021_411","relation":{},"ISSN":["0032-5422"],"issn-type":[{"value":"0032-5422","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11,9]]}}}