{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T19:43:19Z","timestamp":1661370199070},"reference-count":0,"publisher":"Polskie Towarzystwo Biochemiczne (Polish Biochemical Society)","license":[{"start":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T00:00:00Z","timestamp":1661212800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Postepy Biochem"],"abstract":"<jats:p>Pocz\u0119cie dziecka w zaawansowanym wieku rozrodczym (&gt;35 lat) w ostatnich dekadach stale wzrasta, szczeg\u00f3lnie w krajach rozwini\u0119tych. Bezpo\u015bredni wp\u0142yw na odsuwanie decyzji o urodzeniu dziecka maj\u0105 czynniki spo\u0142eczno-ekonomiczne, skuteczne \u015brodki antykoncepcyjne, oraz dost\u0119pno\u015b\u0107 technologii wspomaganego rozrodu (ang. Assisted Reproduction Technologies, ART). Rozr\u00f3d wspomagany umo\u017cliwia sukces rozrodczy osobom diagnozowanym jako niep\u0142odne lub o obni\u017conych mo\u017cliwo\u015bciach naturalnego zaj\u015bcia w ci\u0105\u017c\u0119 z uwagi na wsp\u00f3\u0142istniej\u0105ce patologie lub styl \u017cycia. Badania epidemiologiczne wskazuj\u0105, \u017ce zar\u00f3wno zaawansowany wiek rodzicielski jak i ART s\u0105 zwi\u0105zane z patologiami ci\u0105\u017cy, \u017cycia oko\u0142oporodowego i poporodowego, takimi jak cukrzyca ci\u0105\u017cowa, ryzyko stanu przedrzucawkowego, poronienia, oderwanie \u0142o\u017cyska, por\u00f3d przedwczesny, urodzenie martwego dziecka, zaburzenia neurorozwojowe i pogorszone wska\u017aniki og\u00f3lnego stanu zdrowia potomstwa [1\u20134]. W naszej pracy skupimy si\u0119 na dost\u0119pnych informacjach dotycz\u0105cych zmian metabolicznych zwi\u0119kszaj\u0105cych ryzyko rozwoju chor\u00f3b sercowo-naczyniowych u potomstwa rodzic\u00f3w w zaawansowanym wieku oraz urodzonego przy pomocy ART. Na koniec odniesiemy si\u0119 do \u017ar\u00f3de\u0142 powstawania obserwowanych zaburze\u0144 na poziomie gamety i zarodka, dotycz\u0105cych stresu tlenowego, modyfikacji epigenetycznych oraz uszkodze\u0144 DNA, rozpatruj\u0105c mo\u017cliwe dzia\u0142ania naprawcze.<\/jats:p>","DOI":"10.18388\/pb.2021_457","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T19:09:27Z","timestamp":1661368167000},"source":"Crossref","is-referenced-by-count":0,"title":["P\u00f3\u017ane rodzicielstwo i rozr\u00f3d wspomagany: analiza ryzyka wyst\u0105pienia chor\u00f3b przewlek\u0142ych u potomstwa"],"prefix":"10.18388","author":[{"given":"Maria Florencia","family":"Heber","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hafsa","family":"Gulzar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Musson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Bisogno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kinga","family":"Fic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gra\u017cyna Ewa","family":"Ptak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7609","published-online":{"date-parts":[[2022,8,23]]},"container-title":["Post\u0119py Biochemii"],"original-title":[],"link":[{"URL":"https:\/\/postepybiochemii.ptbioch.edu.pl\/index.php\/PB\/article\/download\/457\/1068","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/postepybiochemii.ptbioch.edu.pl\/index.php\/PB\/article\/download\/457\/1069","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/postepybiochemii.ptbioch.edu.pl\/index.php\/PB\/article\/download\/457\/1068","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T19:09:27Z","timestamp":1661368167000},"score":1,"resource":{"primary":{"URL":"https:\/\/postepybiochemii.ptbioch.edu.pl\/index.php\/PB\/article\/view\/457"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,23]]},"references-count":0,"URL":"https:\/\/doi.org\/10.18388\/pb.2021_457","relation":{},"ISSN":["0032-5422"],"issn-type":[{"value":"0032-5422","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8,23]]}}}