{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T06:04:51Z","timestamp":1670047491100},"reference-count":0,"publisher":"Polskie Towarzystwo Biochemiczne (Polish Biochemical Society)","license":[{"start":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T00:00:00Z","timestamp":1669248000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Postepy Biochem"],"abstract":"<jats:p>Wraz ze wzrostem \u015bredniej d\u0142ugo\u015bci \u017cycia i starzeniem si\u0119 ludzkiej populacji, zwi\u0119ksza si\u0119 odsetek os\u00f3b cierpi\u0105cych na choroby neurodegeneracyjne (NDs). W przypadku choroby Alzheimera (AD), choroby Parkinsona (PD) i stwardnienia zanikowego bocznego (ALS), zaobserwowano wyra\u017an\u0105 dysproporcj\u0119 w zachorowalno\u015bci w zale\u017cno\u015bci od p\u0142ci. Uwa\u017ca si\u0119, \u017ce mo\u017ce to mie\u0107 zwi\u0105zek z wp\u0142ywem steroid\u00f3w p\u0142ciowych na ryzyko wyst\u0105pienia tych chor\u00f3b. Dane epidemiologiczne pokazuj\u0105, \u017ce na AD cz\u0119\u015bciej cierpi\u0105 kobiety, natomiast PD i ALS s\u0105 bardziej rozpowszechnione u m\u0119\u017cczyzn. Liczne badania wskazuj\u0105 na neuroprotekcyjne dzia\u0142anie estrogen\u00f3w i potwierdzaj\u0105, \u017ce czynniki redukuj\u0105ce ich poziom zwi\u0119kszaj\u0105 ryzyko zachorowania na NDs. Odwrotne efekty zaobserwowano dla androgen\u00f3w, chocia\u017c dowiedziono tak\u017ce korzystnego wp\u0142ywu tych hormon\u00f3w. Zrozumienie potencjalnej roli steroid\u00f3w p\u0142ciowych i ich receptor\u00f3w w patogenezie i przebiegu NDs mo\u017ce przyczyni\u0107 si\u0119 do lepszego poznania molekularnych mechanizm\u00f3w le\u017c\u0105cych u pod\u0142o\u017ca tych schorze\u0144, a tym samym do opracowania skuteczniejszych sposob\u00f3w prewencji i leczenia.\n\u00a0<\/jats:p>","DOI":"10.18388\/pb.2021_468","type":"journal-article","created":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T21:26:10Z","timestamp":1670016370000},"source":"Crossref","is-referenced-by-count":0,"title":["Rola steroid\u00f3w p\u0142ciowych w chorobach neurodegeneracyjnych"],"prefix":"10.18388","author":[{"given":"Aleksandra","family":"Sadowska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u0142gorzata","family":"Grzesiak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7609","published-online":{"date-parts":[[2022,11,24]]},"container-title":["Post\u0119py Biochemii"],"original-title":[],"link":[{"URL":"https:\/\/postepybiochemii.ptbioch.edu.pl\/index.php\/PB\/article\/download\/468\/1124","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/postepybiochemii.ptbioch.edu.pl\/index.php\/PB\/article\/download\/468\/1125","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/postepybiochemii.ptbioch.edu.pl\/index.php\/PB\/article\/download\/468\/1124","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T21:26:11Z","timestamp":1670016371000},"score":1,"resource":{"primary":{"URL":"https:\/\/postepybiochemii.ptbioch.edu.pl\/index.php\/PB\/article\/view\/468"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,24]]},"references-count":0,"URL":"https:\/\/doi.org\/10.18388\/pb.2021_468","relation":{},"ISSN":["0032-5422"],"issn-type":[{"value":"0032-5422","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11,24]]}}}