{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T06:28:17Z","timestamp":1772605697969,"version":"3.50.1"},"reference-count":0,"publisher":"Polskie Towarzystwo Biochemiczne (Polish Biochemical Society)","issue":"4","license":[{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Postepy Biochem"],"abstract":"<jats:p>Skeletal muscle is a dynamic tissue involved not only in mechanical functions but also in the regulation of metabolic and immune processes. It secretes signaling molecules known as myokines, which act in autocrine, paracrine, and endocrine ways- affecting both muscle function and other tissues and organs. Well-known myokines include myostatin, IL-6, IL-15, FGF21, and irisin. They regulate muscle mass and strength, promote angiogenesis, maintain glucose and lipid homeostasis, and contribute to immune and anti-cancer responses. Their activity depends on physiological and pathological conditions at both local and systemic levels. Notably, myokine secretion varies with muscle fiber type, influencing their specific biological effects. Understanding how myokines are regulated and function may support the development of new therapies in regenerative medicine, oncology, and metabolic disease treatment.<\/jats:p>","DOI":"10.18388\/pb.2021_629","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T11:22:04Z","timestamp":1765970524000},"page":"301-312","source":"Crossref","is-referenced-by-count":1,"title":["Miokiny jako mediatory komunikacji mi\u0119\u015bniowej \u2013 czy typ w\u0142\u00f3kien mi\u0119\u015bniowych ma znaczenie?","Myokines as mediators of muscle communication \u2013 does muscle fiber type matter?"],"prefix":"10.18388","volume":"71","author":[{"given":"Ma\u0142gorzata","family":"Zimowska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7609","published-online":{"date-parts":[[2025,12,17]]},"container-title":["Post\u0119py Biochemii"],"original-title":[],"link":[{"URL":"https:\/\/postepybiochemii.ptbioch.edu.pl\/index.php\/PB\/article\/download\/629\/1806","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/postepybiochemii.ptbioch.edu.pl\/index.php\/PB\/article\/download\/629\/1810","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T21:39:08Z","timestamp":1767908348000},"score":1,"resource":{"primary":{"URL":"https:\/\/postepybiochemii.ptbioch.edu.pl\/index.php\/PB\/article\/view\/629"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,17]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,1,8]]}},"URL":"https:\/\/doi.org\/10.18388\/pb.2021_629","relation":{},"ISSN":["0032-5422"],"issn-type":[{"value":"0032-5422","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12,17]]}}}