{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T19:42:45Z","timestamp":1777146165444,"version":"3.51.4"},"reference-count":0,"publisher":"Frontiers Media SA","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pharm Pharm Sci"],"abstract":"<jats:p>Purpose: MPTP-induced dopaminergic degeneration is an experimental model commonly used to explore Parkinson\u2019s disease. Cerebral drug transport by ABC transporters in MPTP models has never been reported. \r\nMethods: We have investigated the transport of bromocriptine through the blood-brain barrier (BBB) in a MPTP model to understand the influence of the dopaminergic degeneration on ABCB1 and ABCG2.\r\nResults: We have shown that in MPTP treated mice, bromocriptine is widely distributed to brain (2.3-fold versus control, p<\/jats:p>","DOI":"10.18433\/j3b596","type":"journal-article","created":{"date-parts":[[2016,3,18]],"date-time":"2016-03-18T23:05:40Z","timestamp":1458342340000},"page":"199","source":"Crossref","is-referenced-by-count":13,"title":["Role of Two Efflux Proteins, ABCB1 and ABCG2 in Blood-Brain Barrier Transport of Bromocriptine in a Murine Model of MPTP-Induced Dopaminergic Degeneration"],"prefix":"10.3389","volume":"12","author":[{"given":"Sarah","family":"Vautier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline","family":"Milane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Fernandez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helene","family":"Chacun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucette","family":"Lacomblez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Farinotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2009,8,9]]},"container-title":["Journal of Pharmacy &amp; Pharmaceutical Sciences"],"original-title":[],"deposited":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T13:33:09Z","timestamp":1673616789000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.library.ualberta.ca\/jpps\/index.php\/JPPS\/article\/view\/1521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8,9]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2009,6,18]]}},"URL":"https:\/\/doi.org\/10.18433\/j3b596","relation":{},"ISSN":["1482-1826","1482-1826"],"issn-type":[{"value":"1482-1826","type":"electronic"},{"value":"1482-1826","type":"print"}],"subject":[],"published":{"date-parts":[[2009,8,9]]}}}