{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T03:24:36Z","timestamp":1781234676699,"version":"3.54.1"},"reference-count":0,"publisher":"Knowledge E DMCC","content-domain":{"domain":["kne-publishing.com","knepublishing.com","ajmb.org"],"crossmark-restriction":true},"short-container-title":["AJMB"],"abstract":"<jats:p>Background: The aim of the present study was to investigate the potential of Nanochelating-based copper to accelerate the wound healing process and prevent infection in burn wounds.\r\nMethods: Six to eight-week- old female BALB\/c mice were burned with a 1 cm2 heated copper plate on the left flank and then divided into four treatment groups, treated with C8 (nanochelating-based CuNPs), cold cream (supplementary materials) as a control drug, Silver Sulfadiazine and no treatment, respectively. Skin tissue samples were taken from the mice on days 0, 3, 8, 15 and 24. One piece was fixed in 10% neutral buffered formalin for pathological examination and the others were stored at -80\u00b0C until used for pro-inflammatory and growth factor gene expression.\r\nResults: The healing process in the group treated with 10 mg\/ml C8 was significantly faster, and the survival rate of the mice in this group was significantly higher than in the other groups. The pro-inflammatory genes were expressed and down-regulated earlier in the C8 treated mice. Histopathology confirmed the higher cure rate in the group treated with 10 mg\/ml C8 compared to other control groups.\r\nConclusion: C8 has beneficial effects on the healing of burn wounds and the effective dose of this compound should be further investigated. The present study demonstrates the anti-inflammatory properties of nano-chelate-based copper particles' on mouse skin burns. This research opens up new possibilities in dermatology and burn therapy and highlights the potential of copper-based formulations in the treatment of burn injuries<\/jats:p>","DOI":"10.18502\/ajmb.v17i1.17672","type":"journal-article","created":{"date-parts":[[2025,1,25]],"date-time":"2025-01-25T05:20:27Z","timestamp":1737782427000},"update-policy":"https:\/\/doi.org\/10.18502\/knecrossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Therapeutic Effects of Nanochelating-Based Copper Nanoparticles on Burn Wound  Healing in Mouse Model"],"prefix":"10.18502","author":[{"given":"Hossein","family":"Rezvan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Masoud","family":"Zolhavarieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Nourian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Bayat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somayeh","family":"Kalanaky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saideh","family":"Fakharzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Hafizi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Hassan","family":"Nazaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar","family":"Hamoonnavard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7770","published-online":{"date-parts":[[2025,1,25]]},"container-title":["Avicenna Journal of Medical Biotechnology"],"original-title":[],"link":[{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/AJMB\/article\/download\/17672\/16423","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/AJMB\/article\/download\/17672\/16423","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T14:39:56Z","timestamp":1771943996000},"score":1,"resource":{"primary":{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/AJMB\/article\/view\/17672"},"secondary":[{"URL":"https:\/\/www.ajmb.org\/Article?id=60597","label":"UNIVERSITY"}]},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,25]]},"references-count":0,"URL":"https:\/\/doi.org\/10.18502\/ajmb.v17i1.17672","relation":{},"ISSN":["2008-4625","2008-2835"],"issn-type":[{"value":"2008-4625","type":"electronic"},{"value":"2008-2835","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1,25]]}}}