{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:02:48Z","timestamp":1791475368646,"version":"4.3.4"},"reference-count":0,"publisher":"Knowledge E DMCC","content-domain":{"domain":["kne-publishing.com","knepublishing.com","ajmb.org"],"crossmark-restriction":true},"short-container-title":["AJMB"],"abstract":"<jats:p>Background: Resistance to antimalarial medications, particularly in Plasmodium falciparum (P. falciparum), has emerged as a significant challenge, highlighting the need for innovative therapeutic strategies. Green-synthesized magnesium oxide nanoparticles (MgO NPs) represent a promising approach to therapeutic interventions. This study presents one of the first detailed evaluations of green-synthesized MgO NPs derived from Achillea millefolium (A. millefolium) against both chloroquine-sensitive (3D7) and chloroquine-resistant (K1) P. falciparum strains.\r\nMethods: In this study, MgO NPs were biosynthesized using A. millefolium extracts with varying solvent ratios. The nanoparticles were characterized using UV-Vis, FTIR, FESEM, and DLS techniques. Cytotoxicity was assessed via MTT and hemolysis assays. Their antiplasmodial efficacy was evaluated in vitro against chloroquine-sensitive (3D7) and -resistant (K1) P. falciparum strains.\r\nResults: The synthesized MgO NPs displayed quasi-spherical morphology and nanoscale size. Among tested formulations, the most effective showed IC\u2085\u2080 values of 0.17 mg\/ml for the 3D7 strain and 0.76 mg\/ml for the K1 strain, indicating significant antiplasmodial activity.\r\nConclusion: Green-synthesized MgO NPs using A. millefolium demonstrated potent antiplasmodial activity at low IC\u2085\u2080 concentrations, showing efficacy against both chloroquine-sensitive and -resistant P. falciparum strains. These findings highlight their promise as plant-based nanotherapeutics for malaria treatment.<\/jats:p>","DOI":"10.18502\/ajmb.v17i4.20071","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T09:28:06Z","timestamp":1762248486000},"update-policy":"https:\/\/doi.org\/10.18502\/knecrossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Antiplasmodial Activity of Green-Synthesized MgO Nanoparticles Using Achillea  millefolium Against Chloroquine-Resistant and-Sensitive Plasmodium falciparum"],"prefix":"10.18502","author":[{"given":"Niloufar","family":"Khamsehpour","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haleh","family":"Hanifian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Nateghpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Raeisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Shabani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gholamreza","family":"Hassanpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aram","family":"Khezri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Ahmad","family":"Dehdast","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Farivar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed","family":"Shahsavari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7770","published-online":{"date-parts":[[2025,11,4]]},"container-title":["Avicenna Journal of Medical Biotechnology"],"original-title":[],"link":[{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/AJMB\/article\/download\/20071\/18760","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/AJMB\/article\/download\/20071\/18760","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T14:38:44Z","timestamp":1771943924000},"score":1,"resource":{"primary":{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/AJMB\/article\/view\/20071"},"secondary":[{"URL":"https:\/\/www.ajmb.org\/Article.aspx?id=70626","label":"UNIVERSITY"}]},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,4]]},"references-count":0,"URL":"https:\/\/doi.org\/10.18502\/ajmb.v17i4.20071","relation":{},"ISSN":["2008-4625","2008-2835"],"issn-type":[{"value":"2008-4625","type":"electronic"},{"value":"2008-2835","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11,4]]}}}