{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T21:16:13Z","timestamp":1781212573560,"version":"3.54.1"},"reference-count":0,"publisher":"Negah Scientific Publisher","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CMM"],"abstract":"<jats:p>Background and Purpose: The aim of the current study was to investigate the epidemiology of vulvovaginal candidiasis (VVC) and recurrent VVC (RVVC), as well as the antifungal susceptibility patterns of\u00a0Candida\u00a0species isolates.Materials and Methods: A cross-sectional study was carried out on 260 women suspected of VVC from February 2017 to January 2018. In order to identify\u00a0Candida\u00a0species isolated from the genital tracts, the isolates were subjected to polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) using enzymes\u00a0Msp I\u00a0and sequencing. Moreover, antifungal susceptibility testing was performed according to the Clinical and Laboratory Standards Institute guidelines (M27-A3).Results: Out of 250 subjects, 75 (28.8%) patients were affected by VVC, out of whom 15 (20%) cases had RVVC. Among the\u00a0Candida\u00a0species,\u00a0C. albicans\u00a0was the most common species (42\/95; 44.21%), followed by\u00a0C. lusitaniae\u00a0(18\/95; 18.95%),\u00a0C. parapsilosis\u00a0(13\/95; 13.69%), \u00a0C. glabrata\u00a0(8\/95; 8.42%),\u00a0C. kefyr\u00a0(6\/95; 6.31%),\u00a0C. famata\u00a0(5\/95; 5.26%),\u00a0C. africana\u00a0(2\/95; 2.11%), and\u00a0C. orthopsilosis\u00a0(1\/95; 1.05%), respectively. Multiple\u00a0Candida\u00a0species were observed in 28% (21\/75) of the patients. Nystatin showed the narrowest range of minimum inhibitory concentration (MIC) (0.25-16 \u03bcg\/ml) against all\u00a0Candida\u00a0strains, whereas fluconazole (0.063-64 \u03bcg\/ml) demonstrated the widest MIC range. In the current study,\u00a0C. lusitaniae,\u00a0as the second most common causative agent of VVC, was susceptible to all antifungal agents. Furthermore, 61.1% of\u00a0C. lusitaniae\u00a0isolates were inhibited at a concentration of \u2264 2 \u03bcg\/ml,\u00a0while38.9% (n=7)of them exhibited fluconazole MICs above the epidemiologic cutoff values (ECV).\u00a0Candida\u00a0species showed the highest overall resistance against fluconazole (61.3%), followed by itraconazole (45.2%) and caspofungin (23.7%). All of\u00a0C. albicans\u00a0strains were resistant to itraconazole with a MIC value of \u2265 1 \u03bcg\/ml; in addition, 87.5% of them were resistant to fluconazole. Moreover, 100% and 87.5% of\u00a0C. glabrata\u00a0strains were resistant to caspofungin and fluconazole, respectively.Conclusion:\u00a0As the findings revealed, the majority of VVC cases were caused by non-albicans Candida\u00a0species which were often more resistant to antifungal agents.\u00a0Candida lusitaniae\u00a0generally had fluconazole MICs above the ECV. Given the propensity of\u00a0C. lusitaniae\u00a0to develop resistance under drug pressure, antifungals should be administered with caution. The emergence of these species justify the epidemiological surveillance surveys to watch out the distribution of yeast species.<\/jats:p>","DOI":"10.18502\/cmm.5.4.2062","type":"journal-article","created":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T07:01:07Z","timestamp":1583910067000},"source":"Crossref","is-referenced-by-count":13,"title":["Species distribution and susceptibility profiles of Candida species isolated from vulvovaginal candidiasis, emergence of C. lusitaniae"],"prefix":"10.32598","author":[{"given":"Seyed Ebrahim","family":"Hashemi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahereh","family":"Shokohi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdi","family":"Abastabar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narges","family":"Aslani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahbobeh","family":"Ghadamzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iman","family":"Haghani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"17540","published-online":{"date-parts":[[2019,12,21]]},"container-title":["Current Medical Mycology"],"original-title":[],"link":[{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/CMM\/article\/download\/2062\/1747","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/CMM\/article\/download\/2062\/1747","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T14:53:42Z","timestamp":1671202422000},"score":1,"resource":{"primary":{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/CMM\/article\/view\/2062"},"secondary":[{"URL":"http:\/\/cmm.mazums.ac.ir\/article_97301.html","label":"UNIVERSITY"},{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/CMM\/article\/view\/2062","label":"PUBLISHER"}]},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,21]]},"references-count":0,"URL":"https:\/\/doi.org\/10.18502\/cmm.5.4.2062","relation":{},"ISSN":["2423-3420","2423-3439"],"issn-type":[{"value":"2423-3420","type":"electronic"},{"value":"2423-3439","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12,21]]}}}