{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T11:56:03Z","timestamp":1774266963593,"version":"3.50.1"},"reference-count":0,"publisher":"Knowledge E DMCC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["fid"],"abstract":"<jats:p>Objectives: The focused question of this systematic review was \u201cdoes hyaluronic acid (HA) injection in areas of interdental papillary deficiency reduce black triangles?\u201d\r\nMaterials and Methods: A systematic literature search was performed to find clinical studies on human patients with a minimum of 6-month follow-up, published in English from 2005 to May 2020. There were two outcome variables: black triangle area (BTA) change after treatment at different measurement time points compared with baseline, and patient reported outcome measures (PROMs), when available.\r\nResults: Of eight eligible articles (2 randomized clinical trials (RCTs) and 6 non-randomized, non-placebo controlled clinical studies), seven reported that HA injections had a positive impact on reduction of BTA and subsequent papillary augmentation. Six studies were included in meta-analysis and showed that the intervention led to a pooled reduction percentage of 57.7% in BTA after 6 months. Although there were clinical diversities between the studies, all the studies applied the same concentration of HA (approximately 2%), 2-3 mm apical to the papilla tip in several intervals. Some degrees of relapse were reported in some studies.\r\nConclusion: Within the limits of this study, this systematic review and meta-analysis showed that HA injection can serve as an efficient minimally-invasive treatment for small interdental papillary deficiencies. It is essential to conduct further randomized clinical studies with prolonged follow-ups in order to support this conclusion.<\/jats:p>","DOI":"10.18502\/fid.v20i19.12867","type":"journal-article","created":{"date-parts":[[2023,6,11]],"date-time":"2023-06-11T08:42:39Z","timestamp":1686472959000},"source":"Crossref","is-referenced-by-count":6,"title":["Application of Hyaluronic Acid for Treatment of Interdental Papillary Deficiency: A Systematic Review and Meta-Analysis"],"prefix":"10.18502","author":[{"given":"Jowel","family":"Makdisi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Solmaz","family":"Akbari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farid","family":"Zayeri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hoori","family":"AslRoosta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siamak","family":"Yaghobee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7770","published-online":{"date-parts":[[2023,6,10]]},"container-title":["Frontiers in Dentistry"],"original-title":[],"link":[{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/fid\/article\/download\/12867\/12279","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/fid\/article\/download\/12867\/12279","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T17:32:33Z","timestamp":1734456753000},"score":1,"resource":{"primary":{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/fid\/article\/view\/12867"},"secondary":[{"URL":"https:\/\/fid.tums.ac.ir\/index.php\/fid\/article\/view\/3732","label":"UNIVERSITY"},{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/fid\/article\/view\/12867","label":"PUBLISHER"}]},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,10]]},"references-count":0,"URL":"https:\/\/doi.org\/10.18502\/fid.v20i19.12867","relation":{},"ISSN":["2676-296X"],"issn-type":[{"value":"2676-296X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,10]]}}}