{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T03:27:36Z","timestamp":1788838056338,"version":"build-2803163510"},"reference-count":0,"publisher":"Knowledge E DMCC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJAAI"],"abstract":"<jats:p>Asthma is a respiratory disease; involving millions of people worldwide. The main cause of asthma is allergy and immune response dysregulation. The effects of azithromycin and doxycycline as asthma-controlling drugs were evaluated in this study.\r\nMice asthma model was produced and asthmatic mice were treated with azithromycin (75 mg\/kg, orally) and doxycycline (20 mg\/kg, orally). Eosinophils and neutrophils count, interleukin (IL)-4, IL-5, IL-12, IL-13, and total immunoglobulin E (IgE) levels were measured. Histological study and evaluation of the gene\u2019s expression of Muc5ac, Muc5b, IL-33, COX2, MYD88, and TRAF6 were performed.\r\nAzithromycin and doxycycline did not affect eosinophil and neutrophil percentage, IL-4, IL-5, IL-12, total IgE levels, peribronchial and perivascular inflammation, goblet cell hyperplasia, and gene expression of MYD88, TRAF6, and COX2. Treatment with azithromycin significantly decreased IL-13 level, mucus secretion, and gene expression of IL-33, Muc5ac, and Muc5b; compared to the non-treated asthma group.\r\nAzithromycin administration controls mucus secretion and inflammation. Azithromycin therapy and not doxycycline might be an effective adjuvant option in asthma by reducing mucus in the airway.<\/jats:p>","DOI":"10.18502\/ijaai.v21i2.9220","type":"journal-article","created":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T07:27:44Z","timestamp":1650353264000},"source":"Crossref","is-referenced-by-count":3,"title":["Study Effect of Azithromycin and Doxycycline in Mucus Producing and Inflammatory Signaling Pathways of Allergic Asthma"],"prefix":"10.18502","author":[{"given":"Zhen","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihong","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7770","published-online":{"date-parts":[[2022,4,17]]},"container-title":["Iranian Journal of Allergy, Asthma and Immunology"],"original-title":[],"deposited":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T16:56:52Z","timestamp":1734454612000},"score":1,"resource":{"primary":{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/IJAAI\/article\/view\/9220"},"secondary":[{"URL":"https:\/\/ijaai.tums.ac.ir\/index.php\/ijaai\/article\/view\/3321","label":"UNIVERSITY"},{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/IJAAI\/article\/view\/9220","label":"PUBLISHER"}]},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,17]]},"references-count":0,"URL":"https:\/\/doi.org\/10.18502\/ijaai.v21i2.9220","relation":{},"ISSN":["1735-5249","1735-1502"],"issn-type":[{"value":"1735-5249","type":"electronic"},{"value":"1735-1502","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4,17]]}}}