{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T14:33:31Z","timestamp":1771511611541,"version":"3.50.1"},"reference-count":0,"publisher":"Knowledge E DMCC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJAAI"],"abstract":"<jats:p>Hashimoto's thyroiditis (HT) results from chemoattraction of inflammatory cells toward the thyroid gland by inducing the production of interferon-gamma (IFN\u03b3)-induced protein 10 (IP10) by T helper (Th) 1 cells. Vitamin D may suppress the IFN\u03b3-IP10 axis, but this new function of vitamin D has not yet been investigated in HT patients.\r\nIn an intervention and control group, patients received 50000 IU cholecalciferol or placebo every week for three months, respectively. The CD4+ T cells of 40 patients were isolated, and the mRNA expression levels of vitamin D receptor (VDR), peroxisome proliferator-activated receptors (PPAR)-\u03b1, and PPAR-\u03b3 genes were determined by real-time PCR. ELISA method was used to determine serum levels of vitamin D, tumor necrosis factor-alpha (TNF-\u03b1), IFN-\u03b3, and IP10.\r\nVitamin D levels in the intervention group were significantly higher than in the placebo group after supplementation. PPAR-\u03b1 and PPAR-\u03b3 gene expression levels did not differ significantly between the two groups. The serum\u00a0levels of IP10, IFN\u03b3, and TNF-\u03b1 decreased significantly in the vitamin D group, as well as in the placebo group.\u00a0\u00a0\r\nDuring this study, vitamin D levels significantly increased in the intervention group and inflammatory factors decreased. Based on the similar results obtained in the placebo group, further studies with larger sample sizes and longer intervention times are recommended.<\/jats:p>","DOI":"10.18502\/ijaai.v21i4.10288","type":"journal-article","created":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T07:31:13Z","timestamp":1660635073000},"source":"Crossref","is-referenced-by-count":3,"title":["The Impact of Vitamin D Supplementation on the IFN\u03b3-IP10 Axis in Women with Hashimoto\u2019s Thyroiditis Treated with Levothyroxine: A Double-blind Randomized Placebo-controlled Trial"],"prefix":"10.18502","author":[{"given":"Behrouz","family":"Robat-Jazi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saeed","family":"Mobini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"Chahardoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Mansouri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masoumeh","family":"Nodehi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Esfahanian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Akbar","family":"Saboor-Yaraghi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7770","published-online":{"date-parts":[[2022,8,15]]},"container-title":["Iranian Journal of Allergy, Asthma and Immunology"],"original-title":[],"link":[{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/IJAAI\/article\/download\/10288\/9971","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/IJAAI\/article\/download\/10288\/9971","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T17:07:34Z","timestamp":1734455254000},"score":1,"resource":{"primary":{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/IJAAI\/article\/view\/10288"},"secondary":[{"URL":"https:\/\/ijaai.tums.ac.ir\/index.php\/ijaai\/article\/view\/3297","label":"UNIVERSITY"},{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/IJAAI\/article\/view\/10288","label":"PUBLISHER"}]},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,15]]},"references-count":0,"URL":"https:\/\/doi.org\/10.18502\/ijaai.v21i4.10288","relation":{},"ISSN":["1735-5249","1735-1502"],"issn-type":[{"value":"1735-5249","type":"electronic"},{"value":"1735-1502","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8,15]]}}}