{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T12:07:06Z","timestamp":1772107626313,"version":"3.50.1"},"reference-count":0,"publisher":"Knowledge E DMCC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJM"],"abstract":"<jats:p>Background and Objectives: The ability of Candida albicans to produce biofilm is considered an important pathogenic factor. In addition, the low sensitivity of biofilms to antifungal drugs is a challenge for patients, clinicians, and laboratory workers. We aimed to investigate the effectiveness of luliconazole and caspofungin on the planktonic and biofilm types of C. albicans strains.\r\nMaterials and Methods: Fifty C. albicans from vaginitis, candiduria, gastrointestinal candidiasis, and saliva were examined for antifungal susceptibility against caspofungin and luliconazole using the CLSI M27 guideline. Moreover, the susceptibil- ity of biofilms was detected using 96 well microplates and the MTT method.\r\nResults: The capacity of the isolates to produce biofilm within 2, 6, and 24 h was different, however, all tested isolates pro- duced biofilm after 24 h. Vaginal and esophagitis isolates had a high and low ability for biofilm production during 24-hour incubation. In our study, 90% of isolates were sensitive to caspofungin, while 7.5 and 2.5% of them were intermediate and resistant. The MIC range of all isolates against luliconazole was 0.01562-1 \u00b5g\/mL.\r\nConclusion: The MICs of biofilms were 15.6, and 171.3 higher than that of planktonic cells for caspofungin and luli- conazole, respectively. Moreover, paradoxical and trailing effects occurred at 4 and 32 \u00b5g\/mL of caspofungin and luli- conazole, respectively.<\/jats:p>","DOI":"10.18502\/ijm.v17i4.19261","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:02:11Z","timestamp":1753862531000},"source":"Crossref","is-referenced-by-count":0,"title":["The efficacy of luliconazole and caspofungin on planktonic and biofilm of Candida albicans from different sources"],"prefix":"10.18502","author":[{"given":"Mahboubeh","family":"Shabanzadeh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Rezaei-Matehkolaei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Zarei","family":"Mahmoudabadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7770","published-online":{"date-parts":[[2025,7,27]]},"container-title":["Iranian Journal of Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/IJM\/article\/download\/19261\/17941","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/IJM\/article\/download\/19261\/17941","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T11:19:28Z","timestamp":1772104768000},"score":1,"resource":{"primary":{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/IJM\/article\/view\/19261"},"secondary":[{"URL":"https:\/\/ijm.tums.ac.ir\/index.php\/ijm\/article\/view\/4233","label":"UNIVERSITY"}]},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,27]]},"references-count":0,"URL":"https:\/\/doi.org\/10.18502\/ijm.v17i4.19261","relation":{},"ISSN":["2008-4447","2008-3289"],"issn-type":[{"value":"2008-4447","type":"electronic"},{"value":"2008-3289","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7,27]]}}}