{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T12:03:31Z","timestamp":1772107411727,"version":"3.50.1"},"reference-count":0,"publisher":"Knowledge E DMCC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJM"],"abstract":"<jats:p>Background and Objectives: Coronavirus disease 2019 (COVID-19), due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has expanded rapidly to all over the world. Interleukin-17 is one of the inflammatory cytokines which is highly expressed in the blood of individuals with COVID-19. Our aim in the present survey was to assess the mRNA ex- pression levels of cytokine IL-17A, IL-17F and TNF-\u03b1 in the blood of COVID-19 patients compared with healthy control individuals.\r\nMaterials and Methods: A total of 69 patients including 32 mild patients, 20 severe and 17 asymptomatic patients in com- parison with 25 healthy controls were evaluated. To measure the expression profile of IL-17A and IL-17F in whole blood, quantitative PCR was used.\r\nResults: Asymptomatic, mild, and severe SARS-CoV-2 infections were found to have significantly higher levels of IL-17A and IL-17F mRNAs than the healthy group (fold change IL-17A: 3.778; p= 0.002, 4.003; p= 0.001, 2.608; p= 0.0001 respec- tively, fold change IL-17F: 2.967; p= 0.003, 3.819; p= 0.001, 2.617; p= 0.0012 respectively). TNF-\u03b1 mRNA expression was also measured, which shows an approximately similar increase compared to IL-17 (fold change: 2.726; p= 0.002, 2.383; P= 0.001, 2.631; p= 0.001, respectively).\r\nConclusion: SARS-CoV-2 infection severity was associated with blood levels of IL-17A and IL-17F mRNA.<\/jats:p>","DOI":"10.18502\/ijm.v17i6.20376","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T18:49:33Z","timestamp":1765565373000},"source":"Crossref","is-referenced-by-count":0,"title":["A comparative study on proinflammatory cytokines interleukin-17A and interleukin-17F expressions in whole blood of patients with COVID-19"],"prefix":"10.18502","author":[{"given":"Zeynab","family":"Rahni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed Reza","family":"Mohebbi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed Masoud","family":"Hosseini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahrzad","family":"Shoraka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kambiz","family":"Nabati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahsa Saeedi","family":"Niasar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shabnam","family":"Shahrokh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir","family":"Sadeghi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Reza","family":"Zali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7770","published-online":{"date-parts":[[2025,12,12]]},"container-title":["Iranian Journal of Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/IJM\/article\/download\/20376\/19046","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/IJM\/article\/download\/20376\/19046","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T11:14:47Z","timestamp":1772104487000},"score":1,"resource":{"primary":{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/IJM\/article\/view\/20376"},"secondary":[{"URL":"https:\/\/ijm.tums.ac.ir\/index.php\/ijm\/article\/view\/5009","label":"UNIVERSITY"}]},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,12]]},"references-count":0,"URL":"https:\/\/doi.org\/10.18502\/ijm.v17i6.20376","relation":{},"ISSN":["2008-4447","2008-3289"],"issn-type":[{"value":"2008-4447","type":"electronic"},{"value":"2008-3289","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12,12]]}}}