{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T15:08:18Z","timestamp":1772204898906,"version":"3.50.1"},"reference-count":0,"publisher":"Knowledge E DMCC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJM"],"abstract":"<jats:p>Background and Objectives: Non-O1\/O139 Vibrio cholerae (NOVC) has been associated with extraintestinal infections; however, its isolation from bile remains exceedingly rare. This study reports the identification and comprehensive analysis of a NOVC strain isolated from bile, including its antimicrobial resistance profile, virulence gene content, and molecular characteristics.\r\nMaterials and Methods: A NOVC isolate was obtained from the bile of a patient with a hepatobiliary tumor. The isolate was identified and subjected to antimicrobial susceptibility testing. Whole-genome sequencing was performed to characterize its molecular features, including antimicrobial resistance genes, virulence genes, and relevant genetic mutations.\r\nResults: The NOVC isolate presents a multi-drug resistance phenotype. Corresponding genomic analysis indicates that thisstrain belongs to a novel sequence type (ST1736), carrying various drug resistance genes and virulence factors. Moreover,the blaCTX-M-65extended-spectrum \u03b2-lactamase (ESBL) gene was detected in its chromosomal genome.\r\nConclusion: This study presents the first report of a multidrug-resistant NOVC strain isolated from bile in mainland China.Notably, the ESBL gene blaCTX-M-65was identified chromosomally in NOVC for the first time.<\/jats:p>","DOI":"10.18502\/ijm.v18i1.20906","type":"journal-article","created":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T09:43:44Z","timestamp":1771062224000},"source":"Crossref","is-referenced-by-count":0,"title":["Chromosome-borne blaCTX-M-65 gene in non-O1\/O139 Vibrio cholerae   isolated from bile"],"prefix":"10.18502","author":[{"given":"Haifeng","family":"Mao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinzhe","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danting","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7770","published-online":{"date-parts":[[2026,2,8]]},"container-title":["Iranian Journal of Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/IJM\/article\/download\/20906\/19583","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/IJM\/article\/download\/20906\/19583","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T14:17:06Z","timestamp":1772201826000},"score":1,"resource":{"primary":{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/IJM\/article\/view\/20906"},"secondary":[{"URL":"https:\/\/ijm.tums.ac.ir\/index.php\/ijm\/article\/view\/5322","label":"UNIVERSITY"}]},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,8]]},"references-count":0,"URL":"https:\/\/doi.org\/10.18502\/ijm.v18i1.20906","relation":{},"ISSN":["2008-4447","2008-3289"],"issn-type":[{"value":"2008-4447","type":"electronic"},{"value":"2008-3289","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2,8]]}}}