{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T15:09:13Z","timestamp":1772204953028,"version":"3.50.1"},"reference-count":0,"publisher":"Knowledge E DMCC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJM"],"abstract":"<jats:p>Background and Objectives: Umbilical cord blood-derived platelet gel (CBPG) is rich in growth factors (GFs) and an- timicrobial peptides. This study evaluated its in vitro antibacterial and antifungal activity against dominant nosocomial pathogens.\r\nMaterials and Methods: In this experimental study, CB samples were taken from 12 healthy pregnant women post-cesarean at Motahari Hospital, Jahrom. Platelet -rich plasma (PRP) was isolated using a two-step centrifugation protocol (soft-spin: 200\u00d7g, 10 min; hard spin:1000\u00d7g, 15 min, 22\u00b0C) and activated with calcium and human thrombin to form PG. Antimi- crobial effect of PG was determined against Klebsiella pneumoniae, Methicillin-resistant Staphylococcus aureus (MRSA), Acinetobacter baumannii, Pseudomonas aeruginosa, Candida albicans, Aspergillus spp., and Penicillium spp. using broth microdilution and time-kill assays per CLSI guidelines.\r\nResults: PG exhibited strong bacteriostatic activity against MRSA and K. pneumoniae (MIC 2.2\u20132.8 \u00d7 10\u2078 platelets\/mL; 1.7-1.8 log\u2081\u2080 reduction at 24 h, p &lt; 0.001), while PRP was moderately active and PPP was ineffective. No significant activity was observed against P. aeruginosa or A. baumannii (p= 0.2). PG showed sustained fungistatic effects (MIC: 1.9-4.2\u00d7 10\u2078 platelets\/mL up to 72 h).\r\nConclusion: CBPG exhibits potent bacteriostatic and fungistatic effects, particularly against MDR Gram-positive bacteria, offering a novel autologous antimicrobial.\r\n\u00a0<\/jats:p>","DOI":"10.18502\/ijm.v18i1.20933","type":"journal-article","created":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T09:43:40Z","timestamp":1771062220000},"source":"Crossref","is-referenced-by-count":0,"title":["The antimicrobial effects of cord blood-derived platelet gel on nosocomial pathogens"],"prefix":"10.18502","author":[{"given":"Akbar Hashemi","family":"Tayer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gholamreza","family":"Shokoohi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7770","published-online":{"date-parts":[[2026,2,12]]},"container-title":["Iranian Journal of Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/IJM\/article\/download\/20933\/19586","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/IJM\/article\/download\/20933\/19586","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T14:17:01Z","timestamp":1772201821000},"score":1,"resource":{"primary":{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/IJM\/article\/view\/20933"},"secondary":[{"URL":"https:\/\/ijm.tums.ac.ir\/index.php\/ijm\/article\/view\/4789","label":"UNIVERSITY"}]},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,12]]},"references-count":0,"URL":"https:\/\/doi.org\/10.18502\/ijm.v18i1.20933","relation":{},"ISSN":["2008-4447","2008-3289"],"issn-type":[{"value":"2008-4447","type":"electronic"},{"value":"2008-3289","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2,12]]}}}