{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T11:18:37Z","timestamp":1772018317507,"version":"3.50.1"},"reference-count":0,"publisher":"Knowledge E DMCC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJPA"],"abstract":"<jats:p>Background: We aimed to shed light on the risks of elevated levels of IL-18 in aborted women with toxoplasmosis by evaluating the risk or protective function of alleles or genotypes for single nucleotide polymorphism (SNP) of IL-18 (rs 1946519), which might be related to the susceptibility to toxoplasmosis.\r\nMethods: IL-18 levels in patient and control blood samples were determined using ELISA, and the SNP IL-18 (ra 1946519) was subjected to the high-resolution method.\r\nResults: Compared to healthy pregnant women (HP), the IL-18 serum levels of recurrent abortion with toxoplasmosis (RAWT), recurrent abortion without toxoplasmosis (RAWOT), and healthy non-pregnant (HNP) women decreased with significant differences. Additionally, a strong association between patients and controls was found in the SNP IL-18 data. RAWT and RAWOT with the genotypes AA and AC had significantly lower IL-18 serum levels than women HP, according to the distribution of IL-18 serum levels by SNP.\r\nConclusion: The serum level of IL-18 varied by genotype in patients with substantial differences compared to controls, while the SNP of IL-18 has been linked as a risk factor in toxoplasmosis-infected recurrent abortion women.<\/jats:p>","DOI":"10.18502\/ijpa.v19i4.17161","type":"journal-article","created":{"date-parts":[[2024,12,8]],"date-time":"2024-12-08T03:12:15Z","timestamp":1733627535000},"source":"Crossref","is-referenced-by-count":0,"title":["Single Nucleotide Polymorphism of IL-18 (Rs 1946519) in  Recurrent Aborted Iraqi Women and Its Association with  Toxoplasmosis"],"prefix":"10.18502","author":[{"given":"Sabreen Hadi","family":"Fadhil","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Entsar Jabbar","family":"Saheb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7770","published-online":{"date-parts":[[2024,12,8]]},"container-title":["Iranian Journal of Parasitology"],"original-title":[],"link":[{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/IJPA\/article\/download\/17161\/16684","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/IJPA\/article\/download\/17161\/16684","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T10:27:29Z","timestamp":1772015249000},"score":1,"resource":{"primary":{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/IJPA\/article\/view\/17161"},"secondary":[{"URL":"https:\/\/ijpa.tums.ac.ir\/index.php\/ijpa\/article\/view\/4044","label":"UNIVERSITY"}]},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,8]]},"references-count":0,"URL":"https:\/\/doi.org\/10.18502\/ijpa.v19i4.17161","relation":{},"ISSN":["1735-7020"],"issn-type":[{"value":"1735-7020","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12,8]]}}}