{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:07:30Z","timestamp":1791900450881,"version":"4.3.4"},"reference-count":0,"publisher":"Knowledge E DMCC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJPA"],"abstract":"<jats:p>Background: We aimed to investigate the presence of thyroid peroxidase antibodies (anti-TPO) in women with spontaneous abortion, both with and without toxoplasmosis. This was achieved by evaluating and comparing the serum levels of interleukins IL-4, IL-6, IL-10, IL-17, and TNF-\u03b1 in women who experienced abortion due to toxoplasmosis, categorized by positive and negative anti-TPO status, with those who were toxoplasmosis-negative and also negative for anti-TPO.\r\nMethods: We evaluated the serological presence of IgG and IgM antibodies to Toxoplasma using an ELISA method, in Samarra City, Salah al-Din Governorate, Iraq in 2021-2022. A sample of 153 women with spontaneous abortion were enrolled. We also measured the serum levels of interleukins IL-4, IL-6, IL-10, IL-17, TNF-\u03b1, and anti-TPO using the same technique.\r\nResults: Overall, 103 were Toxoplasma-positive. Of these, 14 had positive anti-TPO results (13.5%), compared to only 3 positive cases among the 50 matched controls who were Toxoplasma-negative (6.0%). The difference between Toxoplasma-positive and Toxoplasma-negative women regarding anti-TPO status was statistically significant for interleukins IL-4 (P=0.010), IL-6 (P=0.017), and IL-10 (P=0.003), but not for IL-17 or TNF-\u03b1. Additionally, the statistical analysis revealed a highly significant difference in the average concentrations of interleukins IL-4 (P=0.013) and IL-10 (P&lt;0.001) between the Toxoplasma-positive\/anti-TPO-positive group and the Toxoplasma-negative\/anti-TPO-negative group of aborted women.\r\nConclusion: Elevated concentrations of IL-4, IL-10, and IL-6 have been associated with women undergoing recurrent miscarriages and negative anti-TPO results. The complex interaction between pro-inflammatory and anti-inflammatory cytokines is essential for immunological balance and pregnancy outcomes in a condition of toxoplasmosis. An increase in IL-4 and IL-10 levels in anti-TPO-positive individuals may lead to an imbalance in immune response, facilitating the development of autoimmune thyroid disease.<\/jats:p>","DOI":"10.18502\/ijpa.v20i2.19050","type":"journal-article","created":{"date-parts":[[2025,7,6]],"date-time":"2025-07-06T16:06:39Z","timestamp":1751817999000},"source":"Crossref","is-referenced-by-count":1,"title":["Interleukin Activity in Miscarried Women with Toxoplasmosis and Anti Thyroid Peroxidase (Anti-TPO)"],"prefix":"10.18502","author":[{"given":"Salah","family":"Alnisani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Rebai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7770","published-online":{"date-parts":[[2025,7,6]]},"container-title":["Iranian Journal of Parasitology"],"original-title":[],"link":[{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/IJPA\/article\/download\/19050\/17763","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/IJPA\/article\/download\/19050\/17763","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T10:25:59Z","timestamp":1772015159000},"score":1,"resource":{"primary":{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/IJPA\/article\/view\/19050"},"secondary":[{"URL":"https:\/\/ijpa.tums.ac.ir\/index.php\/ijpa\/article\/view\/4488","label":"UNIVERSITY"}]},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,6]]},"references-count":0,"URL":"https:\/\/doi.org\/10.18502\/ijpa.v20i2.19050","relation":{},"ISSN":["1735-7020"],"issn-type":[{"value":"1735-7020","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7,6]]}}}