{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T21:44:30Z","timestamp":1774475070574,"version":"3.50.1"},"reference-count":0,"publisher":"Knowledge E DMCC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJPS"],"abstract":"<jats:p>Objective: Manic and mixed episodes of bipolar disorder are important episodes of this disorder. The aim of the current study was to assess serum vitamin D (SVD) levels in patients with mania and mixed bipolar disorder, compared to healthy subjects.\r\nMethod: The current cross-sectional study was conducted on 75 subjects, including healthy subjects (n = 25), patients with acute-phase mania (n = 25), and patients with mixed bipolar disorder (n = 25). The SVD levels were measured in all of the enrolled subjects. The Hamilton Depression Rating Scale (HDRS), Young Mania Rating Scale (YMRS), and Clinical Global Impression- Severity (CGI-S) were used to assess disease activity in patient groups. Data analysis was performed using SPSS version 18. For statistical analysis, analysis of variance (ANOVA), independent-sample t test, Pearson correlation, and Chi-square tests were utilized. P-values &lt; 0.05 were considered statistically significant.\r\nResults: The results showed that the mean of SVD was significantly lower in mania and mixed bipolar patients compared to healthy subjects (P &lt; 0.05). In addition, the number of subjects with SVD \u2265 20 ng\/ml was higher in the healthy group compared to the patient groups (P &lt; 0.05). Also, SVD was negatively correlated with the CGI-S (r = -0.311; P = 0.028), YMRS (r = -0.464; P = 0.001), and HDRS (r = -0.393; P = 0.005) in the total patient subjects.\r\nConclusion: Prevalence of low SVD was considerably high in mania and mixed bipolar patients compared to healthy subjects. Additionally, meaningful negative correlations were found between SVD and disease activity-related variables including the HDRS, YMRS, and CGI-S.<\/jats:p>","DOI":"10.18502\/ijps.v19i3.15803","type":"journal-article","created":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T05:46:52Z","timestamp":1719035212000},"source":"Crossref","is-referenced-by-count":2,"title":["Serum Vitamin D, Mania and Depression-Related Scores: A Comparison among Mixed Bipolar, Mania, and Healthy Subjects"],"prefix":"10.18502","author":[{"given":"Ali Nazeri","family":"Astaneh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neda","family":"Jafari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gita","family":"Sadighi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7770","published-online":{"date-parts":[[2024,6,22]]},"container-title":["Iranian Journal of Psychiatry"],"original-title":[],"link":[{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/IJPS\/article\/download\/15803\/14744","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/IJPS\/article\/download\/15803\/14744","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T10:40:57Z","timestamp":1772016057000},"score":1,"resource":{"primary":{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/IJPS\/article\/view\/15803"},"secondary":[{"URL":"https:\/\/ijps.tums.ac.ir\/index.php\/ijps\/article\/view\/3645","label":"UNIVERSITY"}]},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,22]]},"references-count":0,"URL":"https:\/\/doi.org\/10.18502\/ijps.v19i3.15803","relation":{},"ISSN":["1735-4587","2008-2215"],"issn-type":[{"value":"1735-4587","type":"electronic"},{"value":"2008-2215","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6,22]]}}}