{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:55:32Z","timestamp":1778619332229,"version":"3.51.4"},"reference-count":8,"publisher":"Knowledge E DMCC","issue":"4","content-domain":{"domain":["knepublishing.com"],"crossmark-restriction":true},"short-container-title":["IJRM"],"abstract":"<jats:p>Background: Infertility is characterized by the inability to obtain a successful pregnancy after 6 months or more with unprotected and regular intercourse. In developing countries, the incidence of infertility is 2%. The causes of infertility could be male factor or female factor, or mixed factor.\r\nObjective: This study was conducted with the aim of comparison the ovarian response to letrozole alone and letrozole plus dexamethasone in infertile women with poly cystic ovarian disease (PCOS).\r\nMaterials and Methods: This randomized clinical trial was conducted on 120 infertile women with PCOS referred to Ali-Ebne-Abitaleb hospital, Zahedan, Iran from February to August 2017 into two groups: group I received letrozole alone and group II recived letrozole plus dexamethasone. The endometrial thickness, follicle diameter, and ovulation were evaluated and compared by ultrasound on days 12 to 14.\r\nResults: The mean thickness of endometrium was not different between two groups. Pregnancy rate was 8% in letrozole group and 23% in Letrozole plus Dexamethasone (p = 0.024). Also, the mean diameter of follicles in two groups were not statistically significant.\r\nConclusion: Overall, this study showed that dexamethasone may increase pregnancy rate.\r\nKey words: Letrozole, Dexamethasone, PCOS, Induction ovulation.<\/jats:p>","DOI":"10.18502\/ijrm.v13i4.6893","type":"journal-article","created":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T08:56:04Z","timestamp":1588841764000},"page":"307-310","update-policy":"https:\/\/doi.org\/10.18502\/knecrossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Comparison of ovulation induction with letrozole plus dexamethasone and letrozole alone in infertile women with polycystic ovarian disease: An RCT"],"prefix":"10.18502","volume":"18","author":[{"given":"Farahnaz","family":"Farzaneh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Afshar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7770","published-online":{"date-parts":[[2020,5,5]]},"reference":[{"key":"49053","doi-asserted-by":"crossref","unstructured":"Behnoud N, Bahrami R, Kordafshari G, Farzaneh F, Mohammadi Kenari H. Management of early menopause using traditional Persian medicine. A case report. Int J Women\u2019s Health Reprod Sci 2019; 7: 231\u2013236.","DOI":"10.15296\/ijwhr.2019.39"},{"key":"49054","unstructured":"Behnoud N, Farzaneh F, Ershadi S. The effect of clomiphene citrate versus letrozole on pregnancy rate in women with polycystic ovary syndrome: A randomized clinical trial. Crescent J Med Biol Sci 2019; 6: 335\u2013340."},{"key":"49055","doi-asserted-by":"crossref","unstructured":"Behnoud N, Rezaei R, Esform E, Farzaneh F. The relationship between endometrial thickness and endometrial pattern with pregnancy rate based on positive serum beta-human chorionic gonadotropin. Int J Women\u2019s Health Reprod Sci 2019; 7: 400\u2013403.","DOI":"10.15296\/ijwhr.2019.65"},{"key":"49056","doi-asserted-by":"crossref","unstructured":"Teimoori B, Esmaeilpoor M, Khaefi Ashkezari A, Farzaneh F. Comparison of induction abortion in the first trimester using misoprostol alone and misoprostol with estrogen priming. Int J Women\u2019s Health Reprod Sci 2019; 7: 404\u2013407.","DOI":"10.15296\/ijwhr.2019.66"},{"key":"49057","unstructured":"Al-Shaikh SF, Fadhil I. [Prednisolone with clomiphene citrate in ovulation induction in clomiphene citrateresistant polycystic ovary syndrome]. Med J Babylon 2010; 7: 571\u2013578. (in Arabic)"},{"key":"49058","doi-asserted-by":"crossref","unstructured":"Begum MR, Ehsan M, Begum MS, Khan F, Baby HA, Siddiqui M, et al. Beneficial effects of addition of glucocorticoid during induction of ovulation by letrozole in polycystic ovarian syndrome. J South Asian Federation Obstet Gynecol 2012; 4: 85\u201389.","DOI":"10.5005\/jp-journals-10006-1180"},{"key":"49059","unstructured":"Ashrafi M, Zafarani F, Tehrani E, Owj M, Baghestani AR, Amirchaghmaghi E. [Effect of Dexamethasone on ovarian response in infertile women aged over 35 years undergoing IVF\/ICSI program]. Med J Reprod Infertil 2004; 5: 308\u2013314. (in Persian)"},{"key":"49060","unstructured":"Shabana AA, Al-Halby AE, Shaheen AH, El-Naggar AM. Letrozole with dexamethasone versus clomiphene citrate with dexamethasone for induction of ovulation in polycystic ovary. Menoufa Med J 2018; 31: 38\u201345."}],"container-title":["International Journal of Reproductive BioMedicine (IJRM)"],"original-title":[],"link":[{"URL":"https:\/\/knepublishing.com\/index.php\/ijrm\/article\/download\/6893\/12645","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/knepublishing.com\/index.php\/ijrm\/article\/download\/6893\/12646","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/knepublishing.com\/index.php\/ijrm\/article\/download\/6893\/12645","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T07:46:21Z","timestamp":1737704781000},"score":1,"resource":{"primary":{"URL":"https:\/\/knepublishing.com\/index.php\/ijrm\/article\/view\/6893"},"secondary":[{"URL":"http:\/\/journals.ssu.ac.ir\/ijrmnew\/article-1-1363-en.html","label":"UNIVERSITY"},{"URL":"https:\/\/knepublishing.com\/index.php\/ijrm\/article\/view\/6893","label":"PUBLISHER"}]},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,5]]},"references-count":8,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,5,5]]}},"URL":"https:\/\/doi.org\/10.18502\/ijrm.v13i4.6893","relation":{},"ISSN":["2476-3772","2476-4108"],"issn-type":[{"value":"2476-3772","type":"electronic"},{"value":"2476-4108","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5,5]]}}}