{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T04:36:36Z","timestamp":1754195796212,"version":"3.33.0"},"reference-count":26,"publisher":"Knowledge E DMCC","issue":"3","content-domain":{"domain":["knepublishing.com"],"crossmark-restriction":true},"short-container-title":["IJRM"],"abstract":"<jats:p>Background: Aerva lanata, a herb used as food and also consumed as a tonic by pregnant women to relieve stomach pains and prevent miscarriage. In addition to other characterized properties, it possesses antifertility and anti-implantation activities.\r\nObjective: This study investigates the testicular toxicity of the testes of offsprings of Dams treated with crude aqueous extract of Aerva lanata.\r\nMaterials and Methods: 25 pregnant Wistar rats (Dams) weighing 180-240 gr were randomly earmarked into 5 groups (n = 5\/each). Group A served as control; groups B, C, D, and E received 200, 400, 800, and 1000 mg\/kg body weight of Aerva lanata extract, respectively, beginning from 12th to 19th day of gestation. The pups (delivered of Dams) were weighed, observed, and sacrificed 6 wk post-parturition. The testes of the male pups were obtained for histological procedures the testis histology was examined.\r\nResults: No gross malformation was observed in the treatment groups, the number of pups\/litter was significantly reduced in group E (p = 0.01), pups weight analysis showed a significant reduction in groups C and E (p = 0.04, and 0.02 respectively), and the mean pup testes weight was significantly reduced in groups B, C, D, and E (p = 0.03, 0.03, 0.01, and &lt; 0.001 respectively) when compared with control. Histologically, the treated pup testes tissues showed varying degrees of disruption and distortion of the cellular arrangements of the germinal epithelium in a dose-dependent manner compared to the control.\r\nConclusion: The study revealed a testicular toxicity and possibly antifertility role of Aerva lanata in dams\u2019 pups.\r\nKey words: Amaranthaceae, Fertility, Male fertility, Male reproductive system, Local herbs.<\/jats:p>","DOI":"10.18502\/ijrm.v21i3.13199","type":"journal-article","created":{"date-parts":[[2023,4,16]],"date-time":"2023-04-16T06:16:10Z","timestamp":1681625770000},"page":"237-244","update-policy":"https:\/\/doi.org\/10.18502\/knecrossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Anti-fertility effect of Aerva lanata crude extract in male Dams offspring: An experimental study"],"prefix":"10.18502","volume":"21","author":[{"given":"Raphael Eguono","family":"Uwejigho","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kingsley Afoke","family":"Iteire","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix Udawmojo","family":"Enemali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7770","published-online":{"date-parts":[[2023,4,11]]},"reference":[{"key":"244201","doi-asserted-by":"crossref","unstructured":"Hao D-C. Ranunculales medicinal plants: Biodiversity, chemodiversity and pharmacotherapy. UK: Academic Press; 2019.","DOI":"10.1016\/B978-0-12-814232-5.00009-5"},{"key":"244202","unstructured":"Mintah SO, Asafo-Agyei T, Archer MA, Atta-Adjei Junior P, Boamah D, Kumadoh D, et al. Medicinal plants for treatment of prevalent diseases. In: Perveen Sh, Al-Taweel A. Pharmacognosy: Medicinal plants. UK: Intechopen; 2018."},{"key":"244203","doi-asserted-by":"crossref","unstructured":"Akunne TC, Uzor Ph, Onyeto CA, Okereke EK. Safe African Medicinal plants for clinical studies. In: Kuete V. Toxicological survey of African Medicinal plants. London: Elsevier; 2014: 535\u2013555.","DOI":"10.1016\/B978-0-12-800018-2.00018-2"},{"key":"244204","unstructured":"Karemore MN, Avari JG. Herbal medicines used during pregnancy, childbirth and postpartum care. Int J Pharm Sci Res 2017; 8: 5326\u20135335."},{"key":"244205","doi-asserted-by":"crossref","unstructured":"Musaddiqa S, Mustafaa K, Ahmadb S, Aslama S, Alic B, Khakwania S, et al. Pharmaceutical, ethnopharmacological, phytochemical and synthetic importance of genus Aerva: A review. Natural Product Communications 2018; 13: 375\u2013385.","DOI":"10.1177\/1934578X1801300326"},{"key":"244206","doi-asserted-by":"crossref","unstructured":"Zhao Y, Kumar D, Prasad DN, Singhb RK, Ma Y. Morphoanatomic, physicochemical, and phytochemical standardization with HPTLC fingerprinting of aerial parts of Aerva lanata (Linn) Juss ex schult. J Trad Chinese Med Sci 2015; 2: 39\u201344.","DOI":"10.1016\/j.jtcms.2014.12.002"},{"key":"244207","doi-asserted-by":"crossref","unstructured":"Savadi RV, Alagawadi KR. Antifertility activity of ethanolic extracts of plumbago indica and Aerva lanata on albino rats. Int J Green Pharmcol 2009; 3: 230\u2013233.","DOI":"10.4103\/0973-8258.56281"},{"key":"244208","unstructured":"Carlson B. Human embryology and developmental biology. 5th Ed. Philadelphia: Saunders; 2013."},{"key":"244209","doi-asserted-by":"crossref","unstructured":"Costa KCS, Bezerra SB, Norte CM, Nunes LMN, de Olinda TM. Medicinal plants with teratogenic potential: Current considerations. Braz J Pharm Sci 2012; 48: 427\u2013433.","DOI":"10.1590\/S1984-82502012000300009"},{"key":"244210","unstructured":"Ghuman S, Coopoosamy RM. Crude sample preparation, extraction and in vitro screening for antimicrobial activity of selected wound healing medicinal plants in KwaZulu- Natal, South Africa: A review. J Med Plant Res 2011; 5: 3572\u20133576."},{"key":"244211","doi-asserted-by":"crossref","unstructured":"Kpemissi M, Eklu-Gadegbeku K, Veerapur VP, Potarniche AV, Adi K, Vijayakumar S, et al. Antioxidant and nephroprotection activities of Combretum micranthum: A phytochemical, in-vitro and ex-vivo studies. Heliyon 2019; 5: e01365.","DOI":"10.1016\/j.heliyon.2019.e01365"},{"key":"244212","doi-asserted-by":"crossref","unstructured":"Kpemissi M, Eklu-Gadegbeku K, Veerapur VP, Negru M, Taulescu M, Chandramohan V, et al. Nephroprotective activity of Combretum micranthum G. Don in cisplatin induced nephrotoxicity in rats: In-vitro, in-vivo and in-silico experiments. Biomed Pharmacother 2019; 116: 108961.","DOI":"10.1016\/j.biopha.2019.108961"},{"key":"244213","doi-asserted-by":"crossref","unstructured":"Ema M, Miyawaki E, Kawashima K. Critical period for adverse effects on development of reproductive system in male offspring of rats given di-n-butyl phthalate during late pregnancy. 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Res J Pharm Technol 2020; 13: 1580\u20131586.","DOI":"10.5958\/0974-360X.2020.00286.3"},{"key":"244217","doi-asserted-by":"crossref","unstructured":"Weichbrod RH, Thompson GAH, Norton JN. Management of animal care and use programs in research, education, and testing. 2nd Ed. Boca Raton (FL): CRC Press\/Taylor & Francis; 2018.","DOI":"10.1201\/9781315152189"},{"key":"244218","unstructured":"Athira P, Nair SN. Pharmacognostic review of medicinal plant Aerva lanata. J Pharn Sci Res 2017; 9: 1420\u20131423."},{"key":"244219","doi-asserted-by":"crossref","unstructured":"Omotoso KS, Aigbe FR, Salako OA, Chijioke MC, Adeyemi OO. Toxicological evaluation of the aqueous whole plant extracts of Aerva lanata Juss. ex Schult (Amaranthaceae). J Ethnopharmacol 2017; 208: 174\u2013184.","DOI":"10.1016\/j.jep.2017.06.032"},{"key":"244220","unstructured":"Bitasta M, Madan S. Aerva lanata: A blessing of mother nature. 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