{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T18:25:34Z","timestamp":1755800734249,"version":"3.44.0"},"reference-count":15,"publisher":"Knowledge E DMCC","issue":"6","license":[{"start":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:00:00Z","timestamp":1755648000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["knepublishing.com"],"crossmark-restriction":true},"short-container-title":["IJRM"],"abstract":"<jats:p>Background: Coronavirus disease 2019 (COVID-19) presents a broad spectrum of clinical outcomes and, unlike other coronaviruses, poses significant risks during pregnancy. A primary concern is the potential for vertical transmission from mother to fetus, affecting both maternal and fetal health.\r\nObjective: This study aimed to investigate the placental histopathology and maternal-perinatal outcomes in mothers infected with COVID-19.\r\nMaterials and Methods: In this cross-sectional study, 40 pregnant women referred to Ganjavian hospital, Dezful, Iran for delivery from June-October 2021 were enrolled in 2 groups: group I who were women with COVID-19 on the day of delivery (n = 30) and group II who were women without COVID-19 (n = 10). Placental tissue samples were collected post-delivery to assess histopathological changes and placental weight. Additionally, maternal and neonatal characteristics including maternal age, the number of prior deliveries and pregnancies, gestational age, 1- and 5-min Apgar scores, and maternal oxygen administration, mode of delivery, and neonatal COVID-19 test results, were compared between the groups.\r\nResults: No significant differences were found between the groups regarding maternal age, gestational age, parity, Apgar scores, placental weight, oxygen therapy, or delivery method. However, group I showed significantly higher rates of placental abnormalities such as intravillous fetal thrombosis (p = 0.002), fibrin deposition, lymphocytic infiltration, chorangiosis, edema, intervillous hemorrhage, syncytial node formation, distal villous hypoplasia, and avascular villi (p &lt; 0.001).\r\nConclusion: According to our study, the placental tissue of pregnant women who have been infected with COVID-19 during their third trimester indicates tissue changes that can lead to poor exchanges between mother and fetus.<\/jats:p>","DOI":"10.18502\/ijrm.v23i6.19399","type":"journal-article","created":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T12:16:56Z","timestamp":1755692216000},"update-policy":"https:\/\/doi.org\/10.18502\/knecrossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of COVID-19 infection on placental histopathology and maternal-perinatal outcomes: A cross-sectional study"],"prefix":"10.18502","volume":"23","author":[{"given":"Seyedeh Mahsa","family":"Poormoosavi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Amin","family":"Behmanesh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Pourmotahari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosar","family":"Tavvalapour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sima","family":"Janati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7770","published-online":{"date-parts":[[2025,8,20]]},"reference":[{"key":"286835","doi-asserted-by":"crossref","unstructured":"[1] Khan S, Jun L, Nawsherwan, Siddique R, Li Y, Han G, et al. Association of COVID-19 with pregnancy outcomes in healthcare workers and general women. Clin Microbiol Infect 2020; 26: 788\u2013790.","DOI":"10.1016\/j.cmi.2020.03.034"},{"key":"286836","doi-asserted-by":"crossref","unstructured":"[2] Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: Summary of a report of 72,314 cases from the Chinese Center for Disease Control and Prevention. JAMA 2020; 323: 1239\u20131242.","DOI":"10.1001\/jama.2020.2648"},{"key":"286837","doi-asserted-by":"crossref","unstructured":"[3] Lake MA. What we know so far: COVID-19 current clinical knowledge and research. Clin Med 2020; 20: 124\u2013127.","DOI":"10.7861\/clinmed.2019-coron"},{"key":"286838","doi-asserted-by":"crossref","unstructured":"[4] Shanes ED, Mithal LB, Otero S, Azad HA, Miller ES, Goldstein JA. Placental pathology in COVID-19. Am J Clin Pathol 2020; 154: 23\u201332.","DOI":"10.1093\/ajcp\/aqaa089"},{"key":"286839","doi-asserted-by":"crossref","unstructured":"[5] Liu S, Diao L, Huang C, Li Y, Zeng Y, Kwak-Kim JYH. The role of decidual immune cells in human pregnancy. J Reprod Immunol 2017; 124: 44\u201353.","DOI":"10.1016\/j.jri.2017.10.045"},{"key":"286840","doi-asserted-by":"crossref","unstructured":"[6] Mahyuddin AP, Kanneganti A, Wong JJL, Dimri PS, Su LL, Biswas A, et al. Mechanisms and evidence of vertical transmission of infections in pregnancy, including SARS-CoV-2. Prenat Diagn 2020; 40: 1655\u20131670.","DOI":"10.1002\/pd.5765"},{"key":"286841","doi-asserted-by":"crossref","unstructured":"[7] Gralinski LE, Menachery VD. Return of the Coronavirus: 2019-nCoV. Viruses 2020; 12: 135.","DOI":"10.3390\/v12020135"},{"key":"286842","doi-asserted-by":"crossref","unstructured":"[8] Li Q, Guan X, Wu P, Wang X, Zhou L, Tong Y, et al. Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia. N Engl J Med 2020; 382: 1199\u20131207.","DOI":"10.1056\/NEJMoa2001316"},{"key":"286843","doi-asserted-by":"crossref","unstructured":"[9] Motwani R, Deshmukh V, Kumar A, Kumari C, Raza K, Krishna H. Pathological involvement of placenta in COVID-19: A systematic review. Infez Med 2022; 30: 157\u2013167.","DOI":"10.53854\/liim-3002-1"},{"key":"286844","doi-asserted-by":"crossref","unstructured":"[10] Mulvey JJ, Magro CM, Ma LX, Nuovo GJ, Baergen RN. Analysis of complement deposition and viral RNA in placentas of COVID-19 patients. Ann Diagn Pathol 2020; 46: 151530.","DOI":"10.1016\/j.anndiagpath.2020.151530"},{"key":"286845","doi-asserted-by":"crossref","unstructured":"[11] Argueta LB, Lacko LA, Bram Y, Tada T, Carrau L, Rendeiro AF, et al. Inflammatory responses in the placenta upon SARS-CoV-2 infection late in pregnancy. Iscience 2022; 25: 104223.","DOI":"10.1016\/j.isci.2022.104223"},{"key":"286846","doi-asserted-by":"crossref","unstructured":"[12] Blasco Santana L, Miraval Wong E, \u00c1lvarez-Troncoso J, Sanchez Garcia L, Bartha JL, Regojo-Zapata RM. Maternal and perinatal outcomes and placental pathologic examination of 29 SARS-CoV-2-infected patients in the third trimester of gestation. J Obstet Gynaecol Res 2021; 47: 2131\u20132139.","DOI":"10.1111\/jog.14784"},{"key":"286847","doi-asserted-by":"crossref","unstructured":"[13] Schwartz DA, Avvad-Portari E, Bab\u00e1l P, Baldewijns M, Blomberg M, Bouachba A, et al. Placental tissue destruction and insufficiency from COVID-19 causes stillbirth and neonatal death from hypoxic-ischemic injury. Arch Pathol Lab Med 2022; 146: 660\u2013676.","DOI":"10.5858\/arpa.2022-0029-SA"},{"key":"286848","doi-asserted-by":"crossref","unstructured":"[14] Nascimento ACM, Avvad-Portari E, Meuser-Batista M, Conde TC, de S\u00e1 RAM, Salomao N, et al. Histopathological and clinical analysis of COVID-19-infected placentas. Surg Exp Pathol 2024; 7: 4.","DOI":"10.1186\/s42047-024-00146-4"},{"key":"286849","doi-asserted-by":"crossref","unstructured":"[15] Singh N, Buckley T, Shertz W. Placental pathology in COVID-19: Case series in a community hospital setting. 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