{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T11:06:24Z","timestamp":1779015984052,"version":"3.51.4"},"reference-count":19,"publisher":"Knowledge E DMCC","issue":"3","license":[{"start":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T00:00:00Z","timestamp":1778976000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["knepublishing.com"],"crossmark-restriction":true},"short-container-title":["IJRM"],"abstract":"<jats:p>Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder and a major cause of anovulatory infertility. Serum anti-M\u00fcllerian hormone (AMH), a marker of ovarian reserve, is often elevated in PCOS. However, its predictive value for assisted reproductive technology (ART) outcomes remains unclear due to nonlinear associations.\r\nObjective: This study aimed to evaluate the relationship between serum AMH levels and ART outcomes in women with PCOS undergoing in vitro fertilization or intracytoplasmic sperm injection.\r\nMaterials and Methods: In this cross-sectional study, clinical and laboratory data of 204 infertile women with PCOS who underwent ART cycles between March 2023 and March 2025 at Taleghani hospital, Tehran, Iran, were extracted from their medical records. After excluding 32 cases, AMH of 172 women were assessed both continuously and categorically (&lt; 2.5, 2.5\u20136.5, &gt; 6.5 ng\/mL).\r\nResults: Serum AMH was inversely correlated with gonadotropin dose (r = -0.39) and stimulation days (r = -0.98) and positively correlated with metaphase II oocyte count (r = 0.64) and embryo formation (r = 0.59) (p &lt; 0.0001 for all). Multivariable regression analysis confirmed a nonlinear, inverted-U relationship between AMH and these outcomes, with the most favorable ART. Results observed in women with mid-range AMH levels (2.5\u20136.5 ng\/mL). In addition, outcome measures differed significantly across the 3 AMH categories.\r\nConclusion: AMH is a robust yet nonlinear predictor of ART response in PCOS. Mid-range levels produce the best outcomes. Stratifying by AMH may enhance personalized protocols and ART effectiveness.<\/jats:p>","DOI":"10.18502\/ijrm.v24i3.21114","type":"journal-article","created":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T09:49:50Z","timestamp":1779011390000},"update-policy":"https:\/\/doi.org\/10.18502\/knecrossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Serum anti-M\u00fcllerian hormone and ovarian stimulation parameters in women with polycystic ovary syndrome undergoing assisted reproductive technology: A cross-sectional study"],"prefix":"10.18502","volume":"24","author":[{"given":"Sedighe","family":"Hosseini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saghar","family":"Salehpour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nima","family":"Amiresmaili","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Meshkat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fahimeh","family":"Karimi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7770","published-online":{"date-parts":[[2026,5,17]]},"reference":[{"key":"331343","doi-asserted-by":"crossref","unstructured":"[1] Washington JK, Manivasakan J, Kala PG, Sasikala R. Association of anti-Mullerian hormone and free androgen index level on response to clomiphene citrate in PCOS infertile women. Gynecol Obstet Clin Med 2022; 2: 203\u2013207.","DOI":"10.1016\/j.gocm.2022.11.003"},{"key":"331344","unstructured":"[2] Mohammed ZI, Qasim MT. Correlation of AMH and LH levels in PCOS patients with pregnancy rate. Ann R S C B 2021; 25: 945\u2013951."},{"key":"331345","doi-asserted-by":"crossref","unstructured":"[3] Jabarpour M, Amidi F, Rostami S, Aleyasin A, Aghahosseini M, Khodarahmian M, et al. High anti-M\u00fcllerian hormone strongly correlates with reproductive outcomes in women undergoing assisted reproduction. Clin Lab 2023; 69: 2479\u20132488.","DOI":"10.7754\/Clin.Lab.2023.230524"},{"key":"331346","doi-asserted-by":"crossref","unstructured":"[4] Yuwen T, Yang Z, Cai G, Feng G, Liu Q, Fu H. Association between serum AMH levels and IVF\/ICSI outcomes in patients with polycystic ovary syndrome: A systematic review and meta-analysis. Reprod Biol Endocrinol 2023; 21: 95.","DOI":"10.1186\/s12958-023-01153-y"},{"key":"331347","doi-asserted-by":"crossref","unstructured":"[5] Vale-Fernandes E, Barreiro M, Leal C, Macedo RZ, Tom\u00e9 A, Monteiro MP. Elevated anti-M\u00fcllerian hormone as a prognostic factor for poor outcomes of in vitro fertilization in women with polycystic ovary syndrome. Biomedicines 2023; 11: 3150.","DOI":"10.3390\/biomedicines11123150"},{"key":"331348","doi-asserted-by":"crossref","unstructured":"[6] Moolhuijsen LME, Louwers YV, McLuskey A, Broer L, Uitterlinden AG, Verdiesen RMG, et al. Association between an AMH promoter polymorphism and serum AMH levels in PCOS patients. Hum Reprod 2022; 37: 1544\u20131555.","DOI":"10.1093\/humrep\/deac082"},{"key":"331349","doi-asserted-by":"crossref","unstructured":"[7] Guo Y, Liu S, Hu S, Li F, Jin L. High serum anti-M\u00fcllerian hormone concentrations are associated with poor pregnancy outcome in fresh IVF\/ICSI cycle but not cumulative live birth rate in PCOS patients. Front Endocrinol 2021; 12: 673284.","DOI":"10.3389\/fendo.2021.673284"},{"key":"331350","doi-asserted-by":"crossref","unstructured":"[8] Oumeziane A, Aggad A, Melbani Y, Nanouche F, Barbara S, Djerroudi K, et al. Impact of baseline luteinizing hormone (LH) level and anti-M\u00fcllerian hormone (AMH) on pregnancy outcomes in polycystic ovary syndrome (PCOS) patients undergoing IVF\/ICSI cycle in antagonist protocol. Glob Reprod Health 2023; 8: e0071.","DOI":"10.1097\/GRH.0000000000000071"},{"key":"331351","doi-asserted-by":"crossref","unstructured":"[9] Mohammed LS, Haddad NIA. Relationship between anti-Mullerian hormone (AMH) and other influencing factors with in vitro fertilization (IVF) outcome of Iraqi infertile women. Iraqi J Sci 2024; 65: 4901\u20134911.","DOI":"10.24996\/ijs.2024.65.9.7"},{"key":"331352","doi-asserted-by":"crossref","unstructured":"[10] Liu S, Hong L, Mo M, Xiao S, Wang X, Fan X, et al. Association of antim\u00fcllerian hormone with polycystic ovarian syndrome phenotypes and pregnancy outcomes of in vitro fertilization cycles with fresh embryo transfer. BMC Pregnancy Childbirth 2022; 22: 171.","DOI":"10.1186\/s12884-022-04518-0"},{"key":"331353","doi-asserted-by":"crossref","unstructured":"[11] Rotterdam ESHRE\/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril 2004; 81: 19\u201325.","DOI":"10.1016\/j.fertnstert.2003.10.004"},{"key":"331354","doi-asserted-by":"crossref","unstructured":"[12] Delamuta LC, Fassolas G, Dias JA, de Oliveira Henrique LF, Izzo FPM, Izzo CR. Anti-M\u00fcllerian hormone levels and IVF outcomes in polycystic ovary syndrome women: A scoping review. JBRA Assist Reprod 2024; 28: 299\u2013305.","DOI":"10.5935\/1518-0557.20230059"},{"key":"331355","doi-asserted-by":"crossref","unstructured":"[13] Jaralla NM, Al-Turaihi AM, Alkawaz U, Mossa HAL. Antim\u00fcllerian hormone association with polycystic ovary syndrome and pregnancy outcomes of in vitro fertilization cycles with fresh embryo transfer. J Obstet Gynecol Cancer Res 2024; 9: 435\u2013441.","DOI":"10.30699\/jogcr.9.4.435"},{"key":"331356","doi-asserted-by":"crossref","unstructured":"[14] Vijay AS, Gopireddy MMR, Fyzullah S, Gollapalli P, Maheswari M, Rani U, et al. Association between AMH levels and fertility\/reproductive outcomes among women undergoing IVF: A retrospective study. J Reprod Infertil 2022; 23: 54\u201360.","DOI":"10.18502\/jri.v23i1.8453"},{"key":"331357","doi-asserted-by":"crossref","unstructured":"[15] Heidary Z, Masoumi M, Dashtkoohi M, Sharifinejad N, Dehghan Tarzjani M, Ghaemi M, et al. The association of AMH level with the number and quality of oocytes in women undergoing IVF\/ICSI: A single-center study. J Reprod Infertil 2024; 25: 38\u201345.","DOI":"10.18502\/jri.v25i1.15197"},{"key":"331358","doi-asserted-by":"crossref","unstructured":"[16] van der Ham K, Laven JSE, Tay CT, Mousa A, Teede H, Louwers YV, et al. Anti-M\u00fcllerian hormone as a diagnostic biomarker for polycystic ovary syndrome and polycystic ovarian morphology: Systematic review and meta-analysis. Fertil Steril 2024; 122: 727\u2013739.","DOI":"10.1016\/j.fertnstert.2024.05.163"},{"key":"331359","doi-asserted-by":"crossref","unstructured":"[17] Muharam R, Prasetyo YD, Prabowo KA, Putri YI, Maidarti M, Hestiantoro A. IVF outcome with a high level of AMH: A focus on PCOS versus non-PCOS. BMC Womens Health 2022; 22: 172.","DOI":"10.1186\/s12905-022-01756-4"},{"key":"331360","doi-asserted-by":"crossref","unstructured":"[18] Ko YR, Yu EJ, Park JE, Park JK, Eum JH, Kim TH, et al. Predictive model of IVF outcomes for polycystic ovarian morphology and polycystic ovary syndrome in GnRH antagonist protocol using AMH-MoM and ovarian sensitivity index. J Obstet Gynaecol Res 2024; 50: 1667\u20131674.","DOI":"10.1111\/jog.16009"},{"key":"331361","doi-asserted-by":"crossref","unstructured":"[19] Nikbakht R, Mohammadjafari R, Rajabalipour M, Taheri Moghadam M. Evaluation of oocyte quality in polycystic ovary syndrome patients undergoing ART cycles. Fertil Res Pract 2021; 7: 2.","DOI":"10.1186\/s40738-020-00094-z"}],"container-title":["International Journal of Reproductive BioMedicine (IJRM)"],"original-title":[],"link":[{"URL":"https:\/\/knepublishing.com\/index.php\/ijrm\/article\/download\/21114\/31846","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/knepublishing.com\/index.php\/ijrm\/article\/download\/21114\/31846","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T10:15:16Z","timestamp":1779012916000},"score":1,"resource":{"primary":{"URL":"https:\/\/knepublishing.com\/index.php\/ijrm\/article\/view\/21114"},"secondary":[{"URL":"http:\/\/ijrm.ir\/article-1-3650-en.html","label":"UNIVERSITY"}]},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,17]]},"references-count":19,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,5,17]]}},"URL":"https:\/\/doi.org\/10.18502\/ijrm.v24i3.21114","relation":{},"ISSN":["2476-3772","2476-4108"],"issn-type":[{"value":"2476-3772","type":"electronic"},{"value":"2476-4108","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5,17]]}}}