{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T13:00:23Z","timestamp":1790600423976,"version":"4.1.0"},"reference-count":14,"publisher":"Knowledge E DMCC","issue":"8","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["knepublishing.com"],"crossmark-restriction":true},"short-container-title":["IJRM"],"abstract":"<jats:p>Background: Pemphigoid gestationis is a rare skin disease of pregnancy. It can be misdiagnosed due to its many similarities to other dermatoses of pregnancy, and failure to diagnose can be associated with adverse maternal and fetal outcomes.\r\nCase Presentation: We describe a 19-yr-old Iranian primiparous woman who admitted to the Imam Dermatology Clinic, Ahvaz, Iran, at 35 wk of gestation with extensive blistering lesions. Definite diagnosis was confirmed by skin biopsy, and systemic and topical therapies were initiated. The newborn was delivered by cesarean section at 38 wk of gestation due to ruptured membranes and meconium-stained amniotic fluid. The infant appeared healthy, with no skin manifestations. The disease flared after postpartum corticosteroid tapering, requiring re-escalation of therapy. At 6 wk postpartum, hyperpigmentation was fading without scarring, and pruritus was limited to new lesions.\r\nConclusion: Timely diagnosis and multidisciplinary management of pemphigoid gestationis can prevent adverse maternal and fetal outcomes. The observed meconium passage at 38 wk warrants further investigation into potential fetal effects of this condition.<\/jats:p>","DOI":"10.18502\/ijrm.v24i8.21671","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T12:15:25Z","timestamp":1790597725000},"update-policy":"https:\/\/doi.org\/10.18502\/knecrossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Pemphigoid gestationis: A case report on maternal and neonatal outcomes"],"prefix":"10.18502","volume":"24","author":[{"given":"Azita","family":"Raeisi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farkhondeh","family":"Farzamnia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Bozorgian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7770","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"343910","doi-asserted-by":"crossref","unstructured":"[1] Mart\u00ednez-Calvo J, Correa-Jimenez O, Alfaro-Murillo A. Use of intravenous immunoglobulin in the treatment of pemphigoid gestationis: A case report. Cureus 2024; 16: e71799.","DOI":"10.7759\/cureus.71799"},{"key":"343911","doi-asserted-by":"crossref","unstructured":"[2] Chandra R, Roesyanto-Mahadi ID. Dermoscopic and histopathologic findings in diagnosing postpartum pemphigoid gestationis. J Gen Proced Dermatol Venereol Indones 2024; 8: 7.","DOI":"10.7454\/jdvi.v8i1.1125"},{"key":"343912","doi-asserted-by":"crossref","unstructured":"[3] Ngo M, Gupta R, Hadeler E, Rainwater Y. Recurrent pemphigoid gestationis in the setting of first-trimester spontaneous abortions. JAAD Case Rep 2024; 55: 4\u20136.","DOI":"10.1016\/j.jdcr.2024.10.003"},{"key":"343913","doi-asserted-by":"crossref","unstructured":"[4] Wong JH, Tagoe U, Zengin HB, Amin B, McLellan BN, Cowan M. Pemphigoid gestationis associated with gestational trophoblastic neoplasia: A case report. Gynecol Oncol Rep 2025; 59: 101771.","DOI":"10.1016\/j.gore.2025.101771"},{"key":"343914","unstructured":"[5] Mohammed RSH. Evaluation of complications of pemphigus gravidarum in patients according to meta-analysis. Sarc J Med Sci 2025; 4: 40\u201346."},{"key":"343915","doi-asserted-by":"crossref","unstructured":"[6] Kanwar AJ. Pemphigoid gestationis. Br J Dermatol 2015; 172: 6\u20137.","DOI":"10.1111\/bjd.13457"},{"key":"343916","doi-asserted-by":"crossref","unstructured":"[7] S\u00e4vervall C, Sand FL, Thomsen SF. Pemphigoid gestationis: Current perspectives. Clin Cosmet Investig Dermatol 2017; 10: 441\u2013449.","DOI":"10.2147\/CCID.S128144"},{"key":"343917","doi-asserted-by":"crossref","unstructured":"[8] Ceryn J, Siekierko A, Skibi\u0144ska M, Doss N, Narbutt J, Lesiak A. Pemphigoid gestationis-case report and review of literature. Clin Cosmet Investig Dermatol 2021; 14: 665\u2013670.","DOI":"10.2147\/CCID.S297520"},{"key":"343918","doi-asserted-by":"crossref","unstructured":"[9] Hallaji Z, Mortazavi H, Ashtari S, Nikoo A, Abdollahi M, Nasimi M. Pemphigoid gestationis: Clinical and histologic features of twenty-three patients. Int J Women\u2019s Dermatol 2016; 3: 86\u201390.","DOI":"10.1016\/j.ijwd.2016.11.004"},{"key":"343919","unstructured":"[10] Rassai S, Pazyar N, Alavi SM, Kazerouni A, Feily A. Pemphigoid gestationis: A retrospective study in Southwest Iran. Acta Medica Iranica 2013; 51: 408\u2013410."},{"key":"343920","doi-asserted-by":"crossref","unstructured":"[11] Lipozen\u010di\u0107 J, Ljubojevic S, Bukvi\u0107-Mokos Z. Pemphigoid gestationis. Clin Dermatol 2012; 30: 51\u201355.","DOI":"10.1016\/j.clindermatol.2011.03.009"},{"key":"343921","doi-asserted-by":"crossref","unstructured":"[12] Stefaniak AA, Pereira MP, Zeidler C, St\u00e4nder S. Pruritus in pregnancy. Am J Clin Dermatol 2022; 23: 231\u2013246.","DOI":"10.1007\/s40257-021-00668-7"},{"key":"343922","doi-asserted-by":"crossref","unstructured":"[13] Herman H, Krepelka P, Faridova AT, Trojanova K, Hanacek J, Jaluvkova B, et al. A severe case of pemphigoid gestationis persisting after labour-case report and review of the literature. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2024; 168: 271\u2013275.","DOI":"10.5507\/bp.2023.010"},{"key":"343923","doi-asserted-by":"crossref","unstructured":"[14] Lin L, Zeng X, Chen Q. Pemphigus and pregnancy: Analysis and summary of case reports over 49 years. Saudi Med J 2015; 36: 1033\u20131038.","DOI":"10.15537\/smj.2015.9.12270"}],"container-title":["International Journal of Reproductive BioMedicine (IJRM)"],"original-title":[],"link":[{"URL":"https:\/\/knepublishing.com\/index.php\/ijrm\/article\/download\/21671\/32381","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/knepublishing.com\/index.php\/ijrm\/article\/download\/21671\/32381","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T12:30:16Z","timestamp":1790598616000},"score":1,"resource":{"primary":{"URL":"https:\/\/knepublishing.com\/index.php\/ijrm\/article\/view\/21671"},"secondary":[{"URL":"http:\/\/ijrm.ir\/article-1-3836-en.html","label":"UNIVERSITY"}]},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,28]]},"references-count":14,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,9,28]]}},"URL":"https:\/\/doi.org\/10.18502\/ijrm.v24i8.21671","relation":{},"ISSN":["2476-3772","2476-4108"],"issn-type":[{"value":"2476-3772","type":"electronic"},{"value":"2476-4108","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9,28]]}}}