{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T14:31:15Z","timestamp":1778509875309,"version":"3.51.4"},"reference-count":0,"publisher":"Knowledge E DMCC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"abstract":"<jats:p>Background: Cutaneous leishmaniasis (CL) is a neglected disease whose lesions may cause severe scarring and psy-chosocial impact. Current treatments often face poor patient adherence due to side effects and dosing. Electrospinning enables the incorporation of low-cost, bioactive compounds. Ozonated sunflower oil has shown potential to accelerate wound healing. This study aimed to evaluate electrospun fibers containing ozonated sunflower oil combined with standard anti-Leishmania therapy in lesions caused by\u00a0Leishmania amazonensis\u00a0in an animal model.\r\nMethods: BALB\/c mice (n=5\/group) were infected with\u00a0L. amazonensis\u00a0(MHOM\/BR\/1977\/LTB0016). Treatments in-cluded: meglumine antimoniate alone (MA), MA plus electrospun fiber with ozonated sunflower oil (MOO), MA plus fiber with non-ozonated sunflower oil (MNO) and an untreated control (CTRL). After 30 days, lesion size, parasite load, histology and systemic\/local immune parameters were evaluated.\r\nResults: All the groups exhibited lesion growth (MA 12\u00b10.8%, MOO 24\u00b10.4%, MNO 30\u00b10.8 and CTRL 34\u00b10.9%), but the MA group exhibited less growth. However, in the culture of the paws after the treatment, only in the MOO group, promastigotes did not grow, while the other groups reached titers of 1\/6 (MA), 1\/192 (MNO) and 1\/384 (CTRL). Mac\u00adroscopically, the MA and MOO groups showed complete healing of the lesion. Histologically, the MA group had a thicker epidermis (p&lt;0.05) and the MA and MOO groups presented the lowest amount of cellular infiltration.\r\nConclusion: Treatment of cutaneous leishmaniasis lesions in a mouse model with an electrospun fiber containing ozo\u00adnated oil improved drug treatment, ameliorating lesions and could be explored as an alternative treatment for this para\u00adsitic disease.<\/jats:p>","DOI":"10.18502\/jad.v19i4.21211","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T10:22:32Z","timestamp":1776075752000},"source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of an Electrospun Fiber Loaded with Ozonated Oil for the Treat\u00acment of Leishmaniasis Lesions in an Experimental Model"],"prefix":"10.18502","author":[{"given":"Daniela Patr\u00edcia","family":"Tres","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla Diel","family":"Fabrini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana\u00edna Fatima da","family":"Roza Cunha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana Jurumenha","family":"Barreto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Pastri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tha\u00eds Kaori","family":"Katsumata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel Nardi","family":"Fraga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tha\u00eds Soprani","family":"Ayala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas Cardoso","family":"Dragunski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael Andrade","family":"Menolli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7770","published-online":{"date-parts":[[2026,4,13]]},"container-title":["Journal of Arthropod-Borne Diseases"],"original-title":[],"link":[{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/JAD\/article\/download\/21211\/19702","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/JAD\/article\/download\/21211\/19702","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T13:47:41Z","timestamp":1778507261000},"score":1,"resource":{"primary":{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/JAD\/article\/view\/21211"},"secondary":[{"URL":"https:\/\/jad.tums.ac.ir\/index.php\/jad\/article\/view\/1840","label":"UNIVERSITY"}]},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,13]]},"references-count":0,"URL":"https:\/\/doi.org\/10.18502\/jad.v19i4.21211","relation":{},"ISSN":["2322-2271","1735-7179"],"issn-type":[{"value":"2322-2271","type":"electronic"},{"value":"1735-7179","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4,13]]}}}