{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:52:20Z","timestamp":1791204740686,"version":"4.2.0"},"reference-count":0,"publisher":"Knowledge E DMCC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JFRH"],"abstract":"<jats:p>Objective: We evaluated cardiometabolic burden in women planning assisted reproduction in order to identify subgroups at higher risk of pregnancy complications and cardiovascular disease.\r\nMaterials and methods: In this cross-sectional study we investigated 60 infertile women with BMI\u226525 kg\/m2 referred to the Center for Assisted Reproduction. All women underwent metabolic, anthropometric parameters and ultrasound evaluation of ectopic fat depots.\r\nResults: All women had waist \u226580 cm. We found that 93.3% of women had pathological subcutaneous, 58.3% visceral and 80% para-perirenal fat; all women had fatty liver. Visceral fat and severity of steatosis were significantly related to the presence of metabolic syndrome (OR =5.7; p=0.03). A significant negative correlation between low HDL-c and para-perirenal fat (p&lt;0.0001), a significant positive correlation with fasting plasma glucose and para-perirenal fat (p=0.001) were found. We observed a significant positive correlation between visceral fat and hs-CRP (p=0.002), HOMA-IR (p=0.04) and triglycerides (p=0.002), a significant negative correlation with HDL-c (p=0.05).\r\nConclusion: This study by highlighting a clinically \u201cdangerous liaison\u201d between ectopic fat depots and metabolic\/inflammatory markers, might permit to identify women with a worse metabolic phenotype and encourage lifestyle changes for improving their general and reproductive health together.<\/jats:p>","DOI":"10.18502\/jfrh.v15i2.6453","type":"journal-article","created":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T08:29:01Z","timestamp":1623832141000},"source":"Crossref","is-referenced-by-count":0,"title":["Ectopic Fat Depots and Cardiometabolic Burden: A Possible Dangerous Liaison in Women Planning Assisted Reproduction"],"prefix":"10.18502","author":[{"given":"Michela","family":"Cirillo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Boddi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Elisabetta","family":"Coccia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Attanasio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinzia","family":"Fatini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7770","published-online":{"date-parts":[[2021,6,16]]},"container-title":["Journal of Family and Reproductive Health"],"original-title":[],"link":[{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/JFRH\/article\/download\/6453\/6205","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/JFRH\/article\/download\/6453\/6205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:06:52Z","timestamp":1791202012000},"score":1,"resource":{"primary":{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/JFRH\/article\/view\/6453"},"secondary":[{"URL":"https:\/\/jfrh.tums.ac.ir\/index.php\/jfrh\/article\/view\/1689","label":"UNIVERSITY"},{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/JFRH\/article\/view\/6453","label":"PUBLISHER"}]},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,16]]},"references-count":0,"URL":"https:\/\/doi.org\/10.18502\/jfrh.v15i2.6453","relation":{},"ISSN":["1735-9392","1735-8949"],"issn-type":[{"value":"1735-9392","type":"electronic"},{"value":"1735-8949","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6,16]]}}}