{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T02:06:54Z","timestamp":1777946814257,"version":"3.51.4"},"reference-count":26,"publisher":"Knowledge E DMCC","issue":"2","content-domain":{"domain":["knepublishing.com"],"crossmark-restriction":true},"short-container-title":["JOVR"],"abstract":"<jats:p>Purpose: To assess the subfoveal choroidal thickness (SFCT) in patients with Beh\u00e7et disease (BD) and compare the SFCT in patients with and without ocular BD (OBD) and between patients with active and quiescent phases of the Beh\u00e7et\u2019s posterior uveitis.\r\nMethod: This prospective cross-sectional study was conducted on patients with BD (n = 51) between October 2016 and October 2018. Complete ocular examinations including slit lamp biomicroscopy and fundus examination with dilated pupils were performed for all patients. The SFCT values were compared between patients with and without OBD. Enhanced depth imaging optical coherence tomography (EDI\u2013OCT) was done to measure the SFCT, and wide field fundus fluorescein angiography (WF\u2013FAG) was performed to evaluate the ocular involvement and determine the active or quiescent phases of the Beh\u00e7et\u2019s posterior uveitis. The correlation between the changes of SFCT and the WF-FAG scores was assessed.\r\nResults: One hundred and two eyes of 51 patients with BD, aged 29 to 52 years were studied. Of these, 23 patients were male. The mean age \u00b1 standard deviation in patients with OBD and patients without ocular involvement was 38.71 \u00b1 7.8 and 36.22 \u00b1 10.59 years (P = 0.259) respectively. The mean SFCT in patients with OBD was significantly greater than in patients without OBD (364.17 \u00b1 93.34 vs 320.43 \u00b1 56.70 \u03bcm; P = 0.008). The difference of mean SFCT between the active compared to quiescent phase was not statistically significant when only WF-FAG criteria were considered for activity (368.12 \u00b1 104.591 vs 354.57 \u00b1 58.701 \u03bcm, P = 0.579). However, when the disease activity was considered based on both WF-FAG and ocular exam findings, SFCT in the active group was higher than the inactive group (393.04 \u00b1 94.88 vs 351.65 \u00b1 58.63 \u03bcm, P = 0.060). This difference did not reach statistical significance, but it was clinically relevant.\r\nConclusion: Choroidal thickness was significantly increased in BD patients with ocular involvement; therefore, EDI-OCT could be a noninvasive test for evaluation of ocular involvement in patients with BD. The increased SFCT was not an indicative of activity in OBD; however, it could predict possible ocular involvement throughout the disease course.<\/jats:p>","DOI":"10.18502\/jovr.v16i2.9083","type":"journal-article","created":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T10:28:54Z","timestamp":1620296934000},"page":"195-201","update-policy":"https:\/\/doi.org\/10.18502\/knecrossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation and Comparison of Choroidal Thickness in Patients with Beh\u00e7et Disease with versus without Ocular Involvement"],"prefix":"10.18502","volume":"16","author":[{"given":"Seyedeh","family":"Maryam Hosseini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Negar","family":"Morrovatdar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armin","family":"Hemati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mozghan","family":"Dolatkhah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elham","family":"Bakhtiari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra","family":"Mirfeizi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahdieh","family":"Azimizadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7770","published-online":{"date-parts":[[2021,4,29]]},"reference":[{"key":"113171","doi-asserted-by":"crossref","unstructured":"France R, Buchanan RN, Wilson MW, Sheldon MB Jr. Relapsing iritis with recurrent ulcers of the mouth and genitalia (Behcet\u2019s syndrome). 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