{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T21:42:23Z","timestamp":1777671743151,"version":"3.51.4"},"reference-count":0,"publisher":"Knowledge E DMCC","content-domain":{"domain":["kne-publishing.com","knepublishing.com","jri.ir"],"crossmark-restriction":true},"short-container-title":["JRI"],"abstract":"<jats:p>Background: This phase IV routine care study evaluated ovarian responses when using a biosimilar follitropin alfa r-hFSH (Bemfola\u00ae) for controlled ovarian stimulation (COS) in women undergoing assisted reproductive technology (ART) treatment who were pituitary-suppressed with a gonadotrophin-releasing hormone (GnRH) antagonist.\r\nMethods: This multicenter, prospective, non-comparative, non-interventional study (Germany\/Austria) was conducted with 885 women (Mean age of 34.0\u00b14.4 years) for whom COS with Bemfola\u00ae and GnRH-antagonist for pituitary suppression were applied\u00a0 as part of in vitro fertilization (IVF) treatment with\/without intracytoplasmic sperm injection (ICSI) observing routine clinical-practice protocols. Primary endpoint was the number of retrieved cumulus-oocyte-complexes (COCs).\r\nResults: Among 986 ART cycles, COS was given for 9.9\u00b11.8 days (First-day r-hFSH dose of 220.7\u00b168.9 IU; mean total dose of 2184.3\u00b1837.5 IU). It was revealed that 99.1% of cycles resulted in follicular puncture, with mean of 10.7\u00b16.6 oocytes retrieved. Successful fertilization took place after IVF\/ICSI in 93.8% of follicular punctures. Freeze-all was performed in 14.2% of cycles. Fresh embryo transfer was performed in 76.9% of cycles with follicular puncture; mean day of transfer was 3.5\u00b11.3 and average number of transferred embryos was 1.76\u00b10.50. Clinical pregnancy rate was 30.2% of embryo-transfer cycles and 23.4% of started cycles. Sixty-nine reports of ovarian hy-perstimulation syndrome (7.0% of started cycles) were documented.\r\nConclusion: COS with Bemfola\u00ae in GnRH-antagonist IVF\/ICSI protocols in a routine care setting led to an appropriate ovarian response allowing oocyte retrieval in 99.1% of initiated cases.<\/jats:p>","DOI":"10.18502\/jri.v22i2.5798","type":"journal-article","created":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T07:40:51Z","timestamp":1615966851000},"update-policy":"https:\/\/doi.org\/10.18502\/knecrossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical Efficacy of Follitropin Alfa in GnRH-Antagonist Protocols: A  Prospective Observational Phase IV Study on the Use of Biosimilar Follitropin Alfa r-hFSH in Assisted Reproductive Technology in a Routine Care Setting"],"prefix":"10.18502","author":[{"given":"Georg","family":"Griesinger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thilo","family":"Schill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Sator","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Schenk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan-Steffen","family":"Kr\u00fcssel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7770","published-online":{"date-parts":[[2021,3,17]]},"container-title":["Journal of Reproduction &amp; Infertility"],"original-title":[],"link":[{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/JRI\/article\/download\/5798\/5347","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/JRI\/article\/download\/5798\/5347","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T16:26:20Z","timestamp":1734452780000},"score":1,"resource":{"primary":{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/JRI\/article\/view\/5798"},"secondary":[{"URL":"https:\/\/www.jri.ir\/article\/120104","label":"UNIVERSITY"},{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/JRI\/article\/view\/5798","label":"PUBLISHER"}]},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,17]]},"references-count":0,"URL":"https:\/\/doi.org\/10.18502\/jri.v22i2.5798","relation":{},"ISSN":["2251-676X","2228-5482"],"issn-type":[{"value":"2251-676X","type":"electronic"},{"value":"2228-5482","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3,17]]}}}